Objective
Synaptic transmission is of paramount importance for neuronal circuit integrity; if synapses fail, circuits fail. Transmission of electrical pulses in our brain is critical for normal but also higher brain functions such as learning, memory formation and thought, and understanding the regulatory processes of synaptic transmission may provide insight into neurological and psychiatric disorders, such as Parkinson‟s disease, bipolar disorder and drug addiction that arise from defects in specific neuronal circuits in the brain.
Here, we propose to study novel regulatory mechanisms that operate at the synapse and have the capacity to be major regulators of synaptic plasticity. Our work will include studies of novel synaptic organelles and alternative pathways of synaptic vesicle endocytosis (e.g. clathrin-dependent or kiss-and-run), with a clear link to human disease (e.g. Parkinson‟s Disease). We will use innovative genetic screen approaches in flies and bacteria and study processes that regulate synaptic vesicle trafficking employing imaging, electrophysiology and electron microscopy with the ultimate hope of elucidating mechanisms of normal but also diseased brain function
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology environmental engineering waste management waste treatment processes recycling
- natural sciences biological sciences microbiology bacteriology
- medical and health sciences clinical medicine psychiatry
- natural sciences physical sciences optics microscopy electron microscopy
- medical and health sciences basic medicine neurology parkinson
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-StG_20091118
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
9052 ZWIJNAARDE - GENT
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.