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Molecular studies of synaptic vesicle recycling in health and disease

Objective

Synaptic transmission is of paramount importance for neuronal circuit integrity; if synapses fail, circuits fail. Transmission of electrical pulses in our brain is critical for normal but also higher brain functions such as learning, memory formation and thought, and understanding the regulatory processes of synaptic transmission may provide insight into neurological and psychiatric disorders, such as Parkinson‟s disease, bipolar disorder and drug addiction that arise from defects in specific neuronal circuits in the brain.

Here, we propose to study novel regulatory mechanisms that operate at the synapse and have the capacity to be major regulators of synaptic plasticity. Our work will include studies of novel synaptic organelles and alternative pathways of synaptic vesicle endocytosis (e.g. clathrin-dependent or kiss-and-run), with a clear link to human disease (e.g. Parkinson‟s Disease). We will use innovative genetic screen approaches in flies and bacteria and study processes that regulate synaptic vesicle trafficking employing imaging, electrophysiology and electron microscopy with the ultimate hope of elucidating mechanisms of normal but also diseased brain function

Call for proposal

ERC-2010-StG_20091118
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Host institution

VIB VZW
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Belgium

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Activity type
Research Organisations
Principal investigator
Patrik Verstreken (Prof.)
Administrative Contact
Rik Audenaert (Mr.)
EU contribution
€ 1 498 521,60

Beneficiaries (1)

VIB VZW
Belgium
EU contribution
€ 1 498 521,60
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent

See on map

Activity type
Research Organisations
Principal investigator
Patrik Verstreken (Prof.)
Administrative Contact
Rik Audenaert (Mr.)