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Content archived on 2024-05-30

Adipose tissue mass regulation in lean and obese individuals

Objective

Owing to the increase in obesity, life expectancy may start to decrease in developed countries for the first time in recent history. In humans the generation of fat cells (adipocytes) is a major factor behind the growth of adipose tissue during childhood. The factors determining the fat mass in adults, however, are not fully understood. Increased fat storage in fully differentiated adipocytes, resulting in enlarged fat cells, is well documented and thought to be the most important mechanism whereby fat depots increase in adults. Very little is known about the maintenance of fat cells (adipocytes) in humans, how different fat depots are maintained and how (or if) this is altered in obesity. Recently I developed a method that is based on the incorporation of 14C from nuclear bomb tests into genomic DNA, which allows for the analysis of cell and tissue turnover in humans. Using this novel methodology we now have a strategy for studying cell turnover in humans. One tissue of great interest and significant clinical relevance is adipose tissue. Excess adipose tissue, resulting in obesity, is currently one of the most serious threats to human health on a global level. The current proposal aims to determine the dynamics of human adipose tissue maintenance and investigate any differences in regulation of the fat mass in lean and obese individuals. Understanding the dynamics of adipocyte turnover may shed new light on potential treatments for obesity.

Fields of science (EuroSciVoc)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

ERC-2010-StG_20091118
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Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-SG - ERC Starting Grant

Host institution

KAROLINSKA INSTITUTET
EU contribution
€ 1 500 000,00
Address
NOBELS VAG 5
171 77 STOCKHOLM
Sweden

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

No data

Beneficiaries (1)

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