Objective HIF transcription factors, central mediators of cellular adaptation to critically low oxygen levels (=hypoxia), have been largely studied for their crucial role during cancer development. Our recent findings have unveiled two new major roles of HIF. First, in innate immunity and infection, we demonstrated the key contributions of HIFs in regulating important immune effectors molecules. Second, we highlighted the role of HIFs in iron metabolism as critical regulators of iron absorption in the intestine and in systemic iron homeostasis by regulating the liver synthesis of the iron regulatory hormone, hepcidin.These results open new research areas and our research program, based on unique mouse models of conditional HIFs and hepcidin knockout, will be developed around three main axes.1) define the physiological roles of HIF and hepcidin in different key organs involved in maintaining body iron homeostasis. A detailed understanding of the regulation of iron-related proteins is a prerequisite in the development of therapeutics for iron diseases, which pose a major problem worldwide.2) study the role of hepcidin during bacterial infection and tumorigenesis, two pathological conditions where iron is critically required for the proliferation of the pathogens and for cancer cells to feed their high metabolic activity.3) determine the contribution of HIFs in the initiation of tumor development in response to infection. Indeed, our findings that HIF is stabilized by bacteria, even under normal levels of oxygen, and is an essential component of the inflammation response, let us to speculate that HIFs may be a missing link between infection and cancer by triggering a high chronic inflammatory response. For that, we will use the model of the gastric cancer, whose the initiating event is an infection by Helicobacter Pylori. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsmedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinephysiologyhomeostasis Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-SG-LS4 - ERC Starting Grant - Physiology, Pathophysiology and Endocrinology Call for proposal ERC-2010-StG_20091118 See other projects for this call Funding Scheme ERC-SG - ERC Starting Grant Coordinator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Address Rue de tolbiac 101 75654 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Lyddie Laaland (Ms.) Principal investigator Carole Sophie Isabelle Peyssonnaux (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 1 500 000,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Lyddie Laaland (Ms.) Principal investigator Carole Sophie Isabelle Peyssonnaux (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
