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Artificial vascularised scaffolds for 3D-tissue-regeneration

Objective

The use of bioartificial tissue for regenerative medicine offers great therapeutic potential, but also has to meet high demands with respect to the interaction of the bioartificial devices and natural tissues. Key issues for the successful use of bioartifical tissues as natural tissue replacements are their long term functional stability and biocompatible integration. Up to now, various approaches for the generation of bioartificial tissues have not succeeded due to insufficient nutrition and oxygen supply. Therefore, current tissue engineered products have only been realised for non vascularised tissues such as cartilage.
ArtiVasc 3D will break new ground and overcome these challenges by providing a micro- and nano-scale based manufacturing and functionalisation technology for the generation of fully vascularised bioartificial tissue that enables entire nutrition and metabolism. The bioartificial vascularised skin engineered in ArtiVasc 3D will, for the first time, allow tissue replacement with optimum properties.
ArtiVasc 3D will research and develop an innovative combination of hi-tech engineering such as micro-scale printing, nano-scale multiphoton polymerisation and electro-spinning with biological research on biochemical surface modification and complex cell culture. In a multidisciplinary approach, experts in biomaterial development, cell-matrix interaction, angiogenesis, tissue engineering, simulation, design and fabrication methods work together to generate bioartificial vascularised skin in a fully automated and standardised manufacturing approach.
This bioartificial vascularised skin will be of great value in a vast array of clinical treatments, e.g. as a transplant in trauma treatment. In addition, this new bioartificial vascularised skin will be used as an innovative in vitro skin equivalent for pharmaceutical, cosmetics or chemical substance testing, which represents a promising method to reduce expensive, ethically disputed animal testing.

Field of science

  • /medical and health sciences/health sciences/nutrition
  • /medical and health sciences/medical biotechnology/tissue engineering

Call for proposal

FP7-NMP-2010-LARGE-4
See other projects for this call

Funding Scheme

CP-IP - Large-scale integrating project

Coordinator

FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
Address
Hansastrasse 27C
80686 Munchen
Germany
Activity type
Research Organisations
EU contribution
€ 2 207 375
Administrative Contact
Walter Krause (Mr.)

Participants (16)

VIMECON GMBH
Germany
EU contribution
€ 148 307
Address
Kaiserstrasse 100
52134 Herzogenrath
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Markus Kai (Dr.)
UNITECHNOLOGIES SA
Switzerland
EU contribution
€ 528 562
Address
Bernstrasse 5
3238 Gals
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ivan Calderon (Mr.)
AO-FORSCHUNGSINSTITUT DAVOS
Switzerland
EU contribution
€ 90 054
Address
Clavadelerstrasse 8
7270 Davos Platz
Activity type
Research Organisations
Administrative Contact
Rolf Keller (Mr.)
UNIVERSITY OF EAST ANGLIA
United Kingdom
EU contribution
€ 461 029
Address
Earlham Road
NR4 7TJ Norwich
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alan Walker (Dr.)
ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Germany
EU contribution
€ 309 779
Address
Fahnenbergplatz
79098 Freiburg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Michael Moseler (Prof.)
VEREIN ZUR FORDERUNG VON INNOVATIONEN DURCH FORSCHUNG ENTWICKLUNG UNDTECHNOLOGIETRANSFER EV
Germany
EU contribution
€ 499 316
Address
Pruessingstrasse 27B
D-07745 Jena
Activity type
Research Organisations
Administrative Contact
Ralf Wyrwa (Dr.)
MEDIZINISCHE UNIVERSITAET WIEN
Austria
EU contribution
€ 426 607
Address
Spitalgasse 23
1090 Wien
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ferdinand Mühlbacher (Prof.)
KMS Automation GmbH
Germany
EU contribution
€ 374 999
Address
Im Webertal 20
78713 Schramberg-waldmoesssingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Thomas Kopp (Mr.)
AALTO KORKEAKOULUSAATIO SR
Finland
EU contribution
€ 444 729,80
Address
Otakaari 1
02150 Espoo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Minna Malin (Mrs.)
LOUGHBOROUGH UNIVERSITY
United Kingdom
EU contribution
€ 328 876,80
Address
Ashby Road
LE11 3TU Loughborough
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Raymond Kent (Dr.)
UNIVERSITA DEGLI STUDI DI SALERNO
Italy
EU contribution
€ 374 998,80
Address
Via Giovanni Paolo Ii 132
84084 Fisciano Sa
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Loredana Tammaro (Dr.)
Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH
Germany
EU contribution
€ 444 317
Address
Buerckle De La Camp Platz
44789 Bochum
Activity type
Research Organisations
Administrative Contact
Frank Jacobsen (Dr.)
UNIVERSITAET STUTTGART
Germany
EU contribution
€ 419 739,60
Address
Keplerstrasse 7
70174 Stuttgart
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Günter Tovar (Dr.)
ARTTIC
France
EU contribution
€ 377 632
Address
Rue Du Dessous Des Berges 58A
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Martin Dietz (Dr.)
BEIERSDORF AG
Germany
EU contribution
€ 363 678
Address
Unnastrasse 48
20253 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Wolfgang Meyer-Ingold (Dr.)
GLOBAL CLINICAL TRIALS MANAGEMENT AG

Participation ended

Switzerland
Address
Grabenstrasse 15
7002 Chur
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Stephan Zeiter (Dr.)