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Multifunctional bioresorbable biocompatible coatings with biofilm inhibition and optimal implant fixation

Objective

Most common reasons for revision surgery of implants are loosening (65%), dislocation (9%) and infection (7%). The revision rate of hip replacement surgery is between 10-20%. Rates of implant loss for dental implants is 15% over a 5-year period. Biofilm formation is the major pathogenic factor.

The project, driven by 7 dedicated complementary Hi-Tech SMEs, aims at gaining the scientific and processing knowledge to assist the SMEs in the development of the next generation multi-functional coatings for or thopaedic and dental implants and fixation devices for adequate implant fixation, bioresorbability, bioactivity, biocompatibility as well as biofilm formation inhibiting functionality, that should drastically reduce the currently experienced need for implant revisions due to loosening and infections.

The envisaged radical innovations and major breakthroughs are:
- development of new substrates and coatings with enhanced biocompatibility,
- development of radically new or improvement of existing coating techniques for processing bioresorbable and biocompatible coatings with a graded interface and tailored porosity,
- in-depth understanding of implant substrate/coating/bone interfacial structure, design and engineering of optimal implant fixation,
- knowledge on biofilm formation and inhibition,
- formulation and evaluation of biofilm inhibitors incorporated into the coating.

The project addresses the integration of nanotechnologies, materials science and advanced technologies to improve health and quality of life of European citizens and creating wealth through novel knowledge-based and sustainable products (biomaterials) and processes (coatings), by means of fostering breakthrough applications through the integration of multi-disciplinary research developments.

The project will contribute to a dynamic and competitive knowledge-based economy, sustainable development, and serves the needs of an SME-intensive sector.

Call for proposal

FP6-2004-NMP-SME-4
See other projects for this call

Coordinator

KATHOLIEKE UNIVERSITEIT LEUVEN
Address
Oude Markt 13
Leuven
Belgium

Participants (13)

INSTITUT JOZEF STEFAN
Slovenia
Address
Jamova 39
3000 Ljubljana
LIMA-LTO SPA
Italy
Address
Via Nazionale, 52 - Villanova
San Daniele Del Friuli
HELI PRO, PROIZVODNJA IN RAZVOJ KIRURSKIH IMPLANTATOV, D.O.O.
Slovenia
Address
Alpska Cesta 43
Lesce
AALTO-KORKEAKOULUSAATIO
Finland
Address
Otakaari 1
11000 Fi - Aalto
MICROWAVE ENERGY APPLICATIONS COMPANY NV
Belgium
Address
Kapeldreef 60
Leuven - Heverlee
ALHENIA AG
Switzerland
Address
Täfernstrasse, 39
Baden Dättwil
HEMOTEQ GMBH
Germany
Address
Adenauerstrasse 15
Wuerselen
UNIVERSITAET BAYREUTH.
Germany
Address
Universitaetsstrasse 30
95440 Bayreuth
EUCOMED
Belgium
Address
Place Des Maïeurs 2
Brussels
ADVANCED MICROWAVE ENERGY SYSTEMS BVBA
Belgium
Address
Broekstraat 16
Nevele
HELI PRO, PRODUCTION AND DEVELOPMENT OF SURGICAL IMPLANTS, D.O.O.
Slovenia
Address
Alpska Cesta 43
Lesce
"INSTITUTE OF MECHANICS OF MATERIALS AND GEOSTRUCTURES" SA
Greece
Address
Askiton Street 22
Penteli
LABORATOIRE D'EVALUATION DES MATÉRIELS IMPLANTABLES
France
Address
Technopole Montesquieu
Martillac