Objective
Livestock production efficiency is impaired by helminth infection which is ubiquitous in cattle, sheep and goats world-wide. It causes severely debilitating gastro-intestinal, respiratory and hepatic disorders, dependent on the infecting species. The treatment and prevention of helminth parasitism in livestock continues to rely almost exclusively on the use of anthelmintic drugs, an approach threatened by the global emergence of anthelmintic resistance. An alternative approach is vaccination.
Members of the present consortium (from the EU and Switzerland, North and South America, North and South Africa, Australia, 2 SMEs and 1 major animal health company) have developed prototype vaccines with the predicted required efficacy to control major gastro-intestinal nematode infections of livestock, notably Ostertagia ostertagi in cattle and Haemonchus contortus in sheep, the liver fluke Fasciola hepatica in sheep and cattle with leading positions in subunit vaccine development against Cooperia onchophora, Dictyocaulus viviparus in cattle and the tapeworm Echinococcus granulosus in dogs.
This proposal aims to deliver at least one prototype vaccine to the point of uptake by the commercial sector or through government/philanthropic agencies and this will be addressed by
1) Developing effective native or synthetic vaccines, the latter using novel, molecular expression systems.
2) Defining the protective immune responses induced by these vaccines to order to optimise the structure of the antigens and the method of their delivery.
3) Defining vaccine efficacy with trials in both housed and grazing livestock
4) Providing a platform for training and knowledge exchange which includes participation in training programmes, short exchanges of staff, workshops,and web site provision.
5) Interacting closely with computer modellers, the animal health industry, farmer organisations and other stakeholders to define required vaccine characteristics.
6) Knowledge exchange/dissemination to policy makers, scientists, government departments and the general public.
Fields of science
- medical and health sciencesbasic medicineimmunology
- medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsvaccines
- natural sciencesbiological sciencesbiological behavioural sciencesethologybiological interactions
- social scienceseconomics and businesseconomicsproduction economics
- agricultural sciencesanimal and dairy sciencedomestic animalsanimal husbandry
Call for proposal
FP7-KBBE-2010-4
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Coordinator
EH26 0PZ Penicuik
United Kingdom
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Participants (25)
9000 Gent
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9052 ZWIJNAARDE - GENT
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4 Dublin
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69622 Villeurbanne Cedex
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30559 Hannover
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2333 ZA Leiden
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G12 8QQ Glasgow
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L69 7ZX Liverpool
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14005 Cordoba
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H3A0G4 Montreal
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10101 Rabat
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11200 Montevideo
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0001 Pretoria
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0149010 Sao Paulo
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753 18 Uppsala
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8006 ZURICH
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2020 Sidi Thabet
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Participation ended
CT13 9NJ Sandwich
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9 Dublin
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CAJAMARCA
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CA8 9JY Brampton
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6150 Murdoch Perth
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BT7 1NN Belfast
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Morogoro
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19801 WILMINGTON DELAWARE
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