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Natural products from marine fungi for the treatment of cancer

Objective

The aim of MARINE FUNGI is the demonstration of sustainable exploitation of marine natural resources providing appropriate culture conditions for the underutilised group of marine fungi, thus enabling efficient production of marine natural products in the laboratory and also in large scale cultures, avoiding harm to the natural environment. The focus of MARINE FUNGI are new anti-cancer compounds The project will carry out the characterisation of these compounds to the stage of in vivo proof of concept ready to enter further drug development in order to valorise the results of the project.
MARINE FUNGI covers two approaches to gain effective producer strains:
a) Candidate strains originating from one partner’s strain collection will be characterised and optimised using molecular methods.
b) New fungi will be isolated from unique habitats, i.e. tropical coral reefs, endemic macroalgae and sponges from the Mediterranean. Culture conditions for these new isolates will be optimised for the production of new anti-cancer metabolites.
MARINE FUNGI will develop a process concept for these compounds providing the technological basis for a sustainable use of marine microbial products as result of “Blue Biotech”. The project will explore the potential of marine fungi as excellent sources for useful new natural compounds. This will be accomplished by the formation of a new strongly interacting research network comprising the scientific and technological actors, including 3 SMEs and 2 ICPC partners, necessary to move along the added-value chain from the marine habitat to the drug candidate and process concept. The generated and existing knowledge will be disseminated widely for the valorisation of the project results.

Field of science

  • /natural sciences/biological sciences/microbiology/mycology

Call for proposal

FP7-KBBE-2010-4
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

HELMHOLTZ ZENTRUM FUR OZEANFORSCHUNG KIEL
Address
Wischhofstrasse 1-3
24148 Kiel
Germany
Activity type
Research Organisations
EU contribution
€ 497 166
Administrative Contact
Ursula Frank-Scholz (Mrs.)

Participants (12)

Hypha Discovery Limited
United Kingdom
EU contribution
€ 348 380
Address
Briar Cottages, Bakers Lane 1
SL6 6QH Maidenhead
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Liam Evans (Dr.)
TEKNOLOGIAN TUTKIMUSKESKUS VTT
Finland
EU contribution
€ 343 214
Address
Tekniikantie 4 A
02044 VTT Espoo
Activity type
Research Organisations
Administrative Contact
Sinikka Soirinsuo
AARHUS UNIVERSITET

Participation ended

Denmark
EU contribution
€ 16 594,38
Address
Nordre Ringgade 1
8000 Aarhus C
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jens Laurids Sørensen (Dr.)
CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Germany
EU contribution
€ 340 202
Address
Olshausenstrasse 40
24118 Kiel
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Katrin Cengiz
TEKNOLOGISK INSTITUT
Denmark
EU contribution
€ 274 840,02
Address
Gregersensvej 1
2630 Taastrup
Activity type
Research Organisations
Administrative Contact
Mikael Poulsen (Dr.)
UNIVERSITAS DIPONEGORO
Indonesia
EU contribution
€ 29 400
Address
Prof. Sudarto, Sh St. 1
50275 Semarang
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ocky Karna Radjasa (Dr.)
Universidad de Antofagasta
Chile
EU contribution
€ 62 100
Address
Avenida Angamos 601
5655 Antofagasta
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Cristina Inés Dorador Ortiz (Dr.)
European ScreeningPort GmbH
Germany
EU contribution
€ 322 965,80
Address
Schnackenburgallee
22525 Hamburg
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Philip Gribbon (Dr.)
PROBIODRUG AG

Participation ended

Germany
EU contribution
€ 5 858,60
Address
Weinbergweg 22
06120 Halle
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Kerstin Kühn-Wache (Dr.)
UNIVERSITETET I OSLO
Norway
EU contribution
€ 307 948
Address
Problemveien 5-7
0313 Oslo
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Ragni Indahl (Ms.)
AALBORG UNIVERSITET
Denmark
EU contribution
€ 417 829,20
Address
Fredrik Bajers Vej 7K
9220 Aalborg
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Witold Szwebs (Mr.)
REGION SYDDANMARK
Denmark
EU contribution
€ 33 400
Address
Damhaven 12
7100 Vejle
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Lars Weber Strate (Mr.)