Objective Assessment of repeated dose toxicity is a standard requirement in human safety evaluation and relies on animal testing as no alternatives are currently accepted for regulatory purposes. An integrated research strategy for the replacement of animal tests needs to comprise the development of biomarkers of long-term toxicity in human target cells. To this aim, the DETECTIVE project will set up a screening pipeline of high content, high throughput as well as classical functional and “-omics” technologies to identify and investigate human biomarkers in cellular models for repeated dose in vitro testing. In view of industrial use in automated high throughput systems, essential questions of repeated dose toxicity such as stability and robustness of readouts will be investigated in a first phase. This will be the foundation for innovative biomarker development based on integration of multiple data streams derived from “-omics” readouts with traditional toxicological and histopathological endpoint evaluation. Toxicity pathways identified in “-omics” readouts can thus be further investigated by the functional readouts.DETECTIVE will initially use human hepatic, cardiac and renal models as common target organs of repeated dose toxicity. Ultimately, the strategy for establishing biomarkers will also be applicable to other organs or organ systems affected by systemic toxicants. It is also expected that DETECTIVE will be able to define human toxicity pathways relevant for all organs.Based on integrative statistical analysis, systematic verification and correlation with in vivo data, the most relevant, highly specific, sensitive and predictive biomarkers will be selected. Within DETECTIVE, partners from academia, industry and research will hence generate pathway- and evidence-based understanding of toxic effects, moving toxicology beyond descriptive science towards mechanism-based prediction. Fields of science medical and health sciencesbasic medicinetoxicology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2010.4.2-9-3 - Establishment of endpoints and intermediate markers in human-based target cells with relevance for repeated dose systemic toxicity testing. FP7-HEALTH-2010-Alternative-Testing-Strategies Call for proposal FP7-HEALTH-2010-Alternative-Testing See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator KLINIKUM DER UNIVERSITAET ZU KOELN Address Kerpener strasse 62 50937 Koeln Germany See on map Region Nordrhein-Westfalen Köln Köln, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Jürgen Hescheler (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 092 420,01 Participants (14) Sort alphabetically Sort by EU Contribution Expand all Collapse all JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION Belgium EU contribution € 315 388,00 Address Rue de la loi 200 1049 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Research Organisations Administrative Contact Iain Formosa (Mr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITEIT MAASTRICHT Netherlands EU contribution € 442 026,50 Address Minderbroedersberg 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Administrative Contact René Reijnders (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ROCHE DIAGNOSTICS GMBH Germany EU contribution € 168 655,50 Address Sandhofer strasse 116 68305 Mannheim See on map Region Baden-Württemberg Karlsruhe Mannheim, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Manuel Wölfelschneider (Dr.) Links Contact the organisation Opens in new window Website Opens in new window VRIJE UNIVERSITEIT BRUSSEL Belgium EU contribution € 347 858,80 Address Pleinlaan 2 1050 Bruxelles / brussel See on map Region Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad Activity type Higher or Secondary Education Establishments Administrative Contact Maria Vereeken (Ms.) Links Contact the organisation Opens in new window Website Opens in new window PROTEOSYS AG Participation ended Germany EU contribution € 147 914,50 Address Carl zeissstrasse 51 55129 Mainz See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact André Schrattenholtz (Prof.) Links Contact the organisation Opens in new window Website Opens in new window FORSCHUNGSGESELLSCHAFT FUR ARBEITSPHYSIOLOGIE UND ARBEITSSCHUTZ EV Germany EU contribution € 342 556,50 Address Ardeystrasse 67 44139 Dortmund See on map Region Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Jan Hengstler (Prof.) Links Contact the organisation Opens in new window Website Opens in new window IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 307 681,90 Address South kensington campus exhibition road SW7 2AZ London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG Germany EU contribution € 153 000,00 Address Im neuenheimer feld 280 69120 Heidelberg See on map Region Baden-Württemberg Karlsruhe Heidelberg, Stadtkreis Activity type Research Organisations Administrative Contact Krischek Ina (Dr.) Links Contact the organisation Opens in new window Website Opens in new window ARTTIC France EU contribution € 354 266,26 Address 39 rue des mathurins 75008 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Annette Ringwald (Ms.) Links Contact the organisation Opens in new window Website Opens in new window OU QURETEC Estonia EU contribution € 72 686,40 Address Ulikooli 6a 51003 Tartu See on map Region Eesti Eesti Lõuna-Eesti Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jaak Vilo (Prof.) Links Contact the organisation Opens in new window MEDIZINISCHE UNIVERSITAT INNSBRUCK Austria EU contribution € 137 636,00 Address Christoph probst platz 1 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Higher or Secondary Education Establishments Administrative Contact Walter Pfaller (Prof.) Links Contact the organisation Opens in new window Website Opens in new window LEIBNIZ-INSTITUT FUR ANALYTISCHE WISSENSCHAFTEN-ISAS-EV Germany EU contribution € 193 333,50 Address Bunsen kirchhoff strasse 11 44139 Dortmund See on map Region Nordrhein-Westfalen Arnsberg Dortmund, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Albert Sickmann (Prof.) Links Contact the organisation Opens in new window Website Opens in new window FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV Germany EU contribution € 82 285,00 Address Hansastrasse 27c 80686 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Andrea Zeumann (Ms.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITEIT LEIDEN Netherlands EU contribution € 179 716,46 Address Rapenburg 70 2311 EZ Leiden See on map Region West-Nederland Zuid-Holland Agglomeratie Leiden en Bollenstreek Activity type Higher or Secondary Education Establishments Administrative Contact Ton Brouwer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window
