Objective The development of new innovative approaches for personalised healthcare, and the recognition and sensing of environmentally important pollutants resulting from anthropogenic activities, are extremely important areas in which chemical understanding can contribute enormously to the improved well-being of humanity. In particular, the recognition of anions in aqueous media remains a significant challenge. This project will exploit cation-anion interactions augmented by supramolecular chemistry in the preparation of novel heteroditopic receptor molecules for lanthanide cation- anion ion pair recognition. These have the potential to revolutionise magnetic resonance imaging for personalised healthcare, and will provide interlocked host systems capable of sensing and analyte induced molecular motion. Particular emphasis will be given to the construction of heteroditopic macrocyclic and interlocked host systems designed to recognise lanthanide cation-fluoride anion ion pairs. The stimulus for recognising the fluoride anion stems from its duplicitous nature, where for example high levels in drinking water is causing dental and skeletal fluorosis. In stark contrast, importantly for personalised healthcare, fluoride anion recognition offers the potential development of novel 19F MRI and 18-fluoride PET imaging agents. The programme of work in this proposal centres around three closely integrated and synergistic strands. The common theme is to exploit lanthanide- fluoride ion pair recognition in multimodal imaging (Strand 1), to construct interlocked host structures for fluoride recognition, sensing and molecular machine-like induced switchable behaviour (Strand 2), and to assemble interlocked host systems onto transducing surfaces for analyte induced molecular switching (Strand 3). Fields of science engineering and technologyenvironmental engineeringwater treatment processesdrinking water treatment processesmedical and health sciencesclinical medicineradiologynuclear medicineengineering and technologyelectrical engineering, electronic engineering, information engineeringelectronic engineeringsensorsengineering and technologymedical engineeringdiagnostic imagingmagnetic resonance imaging Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-PE5 - ERC Advanced Grant - Materials and Synthesis Call for proposal ERC-2010-AdG_20100224 See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Coordinator THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD Address Wellington square university offices OX1 2JD Oxford United Kingdom See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Principal investigator Paul Derek Beer (Prof.) Administrative Contact Gill Wells (Ms.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 2 488 849,00 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Principal investigator Paul Derek Beer (Prof.) Administrative Contact Gill Wells (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
