Objective
This proposal aims at the development of novel nanostructured materials based on crystalline assemblies of anisotropic plasmonic (gold/silver) nanoparticles, to be used for the surface enhanced Raman scattering (SERS) detection of quorum sensing (QS) signaling molecules, and to the demonstration of applications of such materials to monitor population kinetics in bacterial colonies and the determination of the interaction mechanisms between mixed colonies and their manipulation through external parameters. This will involve a first stage related to the careful design of the most appropriate nanoparticle morphology and composition, as well as an understanding of their specific assembly processes (both on substrates and in solution), so that the collective plasmonic response will be optimized towards the enhancement of the Raman signal of the probe molecular codes. Coating of the nanoparticle supercrystals with a mesoporous layer will be required to protect them against contact with bacteria and cells, while permitting contact with the QS signaling molecules. Ultimately, when the sensing system has been optimized and its performance demonstrated for monitoring of QS signals and colony growth, two final and important goals will be pursued. First, the interaction between mixed colonies (bacteria-bacteria and bacteria-eukaryotic cell) will be monitored in order to get information about synergic or antagonist (toxicity) QS mechanisms during the growth and proliferation of different bacteria and interspecies. This goal will permit the design of in vitro experiments where a bacterial strain may be manipulated by means of external introduction of the appropriate QS signaling molecules. Finally, the major challenge will be the practical demonstration of the ability of these new materials in this particular configuration for understanding and manipulating the growth and communication of different types of prokaryotic and peukaryotic cells.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences chemical sciences inorganic chemistry transition metals
- engineering and technology materials engineering coating and films
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- engineering and technology nanotechnology nano-materials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
ERC-2010-AdG_20100224
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Host institution
20009 San Sebastian
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.