Objective
Defining the mechanisms by which cells cooperate to form complex structures and a common function is a fundamental problem in both developmental biology and socio-biology. Cooperative interactions among bacteria are a relatively simple, yet medically important, model system where this problem can be explored in its full generality. Specifically, bacterial growth on surfaces is often accompanied by formation of complex patterns and increased resilience to diverse external insults. The importance of multiple co-existing cellular differentiated states and of specific cell signaling processes, to spatial patterning and development of bacterial communities has been demonstrated in several systems, including the well-characterized microbe, Bacillus subtilis. However, the nature of these interactions and the way they control the spatial organization of differentiation and patterning is unclear. Specifically, we do not understand (1) when and where are genes and cell fates expressed? (2) What is the spatial organization of cell fates? (3) How does the interaction between fates give rise to spatial order? Here, we suggest addressing these questions by utilizing a novel light-activated gene expression system. This will be used to control the spatial and temporal gene expression profile of a library of patterning-related genes. Time-lapse fluorescence microscopy will be used to monitor the dynamic expression of relevant reporters in wild-type and spatially perturbed backgrounds. We will use mathematical modeling to integrate the results into a predictive model of pattern formation and community development. My previous experience in mathematical modeling of spatial systems, and experimental background in developmental genetics, microbiology and advanced microscopy provides a well suited background to successfully pursue this important problem.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences cell biology cell signaling
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences developmental biology
- natural sciences physical sciences optics microscopy
- natural sciences mathematics applied mathematics mathematical model
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69978 Tel Aviv
Israel
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.