Objective
Heterochromatin is a conserved organizational structure of the genetic material that is indispensable for cell viability. Heterochromatin is associated with the formation of functionally conserved centromeric and telomeric structures. These structures are both essential for the integrity and proper segregation of the genetic material during mitosis and meiosis. Heterochromatin structure is also implicated in programming patterns of genes expression, in particular during cellular differentiation. Several evolutionary conserved molecular pathways have been implicated in the initiation, propagation and maintenance of heterochromatic domains during cell divisions. However, the formation of heterochromatin is an intricate process and despite much research many facets remain to be understood. The overall goal of this proposed research is to gain insight into the formation and maintenance of heterochromatin. The first aim of this study will propose experiments designed to analyze the contribution of the centromere CENP-B proteins to heterochromatin organization and gene expression in the genetically tractable model organism S. pombe. CENP-B are evolutionarily conserved sequence-specific DNA-binding proteins that associate not only with centromeric heterochromatin but also with the heterochromatin of silenced genes and the mating-type locus in yeast. Different studies point to an important role of the CENP-B proteins in heterochromatin formation at several locations in the genome, but their exact molecular role(s) is still debated. The second part of this study will aim to identify additional proteins involved in heterochromatin formation by means of a two-step genome-wide screen in the fission yeast. This screen will be based on properties of centromeric heterochromatin and is anticipated to increase our knowledge of the different pathways controlling heterochromatin formation and maintenance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences genetics heredity
- natural sciences biological sciences genetics genomes
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-RG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
08028 Barcelona
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.