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Leukemic Stem Cells in Chronic Lymphocytic Leukemia

Periodic Report Summary - LSC CLL (Leukemic Stem Cells in Chronic Lymphocytic Leukemia)

We obtained the following results:

1) identified TGFßRIII as a novel marker for understanding CLL biology, demonstrating that the small portion of the clone bearing the receptor on surface membrane has high CXCR4 levels thus is likely attempting to re-enter a solid lymphoid tissue;
2) identified a large panel of proteins highly correlating with in vivo measured cell proliferation;
3) demonstrated the presence of miR-126 in CLL clones; its possible role has to be elucidated enlarging the number of samples studied;
4) prepared the needs for beginning an in vivo study of cell kinetics in cancer in an Institution that never has performed this kind of studies