Objective The evolution of drug resistance and its control represents a considerable challenge in very different biological contexts ranging from pesticide resistance in agriculture to antimicrobial resistance in clinical settings and even extends beyond infectious pathogens, as resistance also evolves in cancer chemotherapy. Naturally, the recommendations for the optimal use of drugs to minimise resistance differ for different biological contexts. In some cases, similar strategies for vastly different pathogens or biological contexts are recommended, whereas in other cases opposing strategies for similar pathogens are advised. To which extent these discrepancies in treatment recommendations are attributable to specific properties of the pathogen, the host, or the general biological context is currently unclear. The aim of this proposal is to develop an integrative population biological framework for the evolution of resistance and its control. To this end we will develop mathematical models of resistance evolution in viruses, bacteria, parasites, cancer and fungal plant pathogens. Developing detailed population biological models that account for the specific biology of these ¿pathogens¿ as well as the specific context of the application of drugs will allow us to identify those aspects that are common between different biological contexts and those aspects that are specific to the pathogen, the host or the drug. Moreover, working simultaneously on resistance evolution in these different biological contexts will facilitate the translation of findings between fields of research that to date have remained largely separate. We seek to bridge these fields and integrate insight to develop a broad conceptual framework with which to address the ever-growing problem of sustainable drug use. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesmicrobiologyvirologymedical and health sciencesclinical medicineoncologymedical and health sciencesbasic medicinepharmacology and pharmacydrug resistanceantibiotic resistancenatural sciencesmathematicsapplied mathematicsmathematical model Programme(s) FP7-IDEAS-ERC - Specific programme: "Ideas" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) ERC-AG-LS8 - ERC Advanced Grant - Evolutionary, population and environmental biology Call for proposal ERC-2010-AdG_20100317 See other projects for this call Funding Scheme ERC-AG - ERC Advanced Grant Coordinator EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Address Raemistrasse 101 8092 Zuerich Switzerland See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Sebastian Bonhoeffer (Prof.) Principal investigator Lukas Sebastian Bonhoeffer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Beneficiaries (1) Sort alphabetically Sort by EU Contribution Expand all Collapse all EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 2 272 403,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Administrative Contact Sebastian Bonhoeffer (Prof.) Principal investigator Lukas Sebastian Bonhoeffer (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
