Objective The importance of carbon-based materials in biological applications has been recognized. Especially, nanodiamond particles (referred to as nanodiamonds, NDs) have started to emerge as novel candidate for promising applications in the field of nano-biotechnology as imaging probes and drug carriers. NDs do not show the toxicity of other nanoparticles, notably gold, making them ideal nanoscale drug delivery platforms. Furthermore, NDs can exhibit intrinsic fluorescence from point defects making them candidates for biomedical imaging applications. ND particles are particularly attractive for biomedical applications as functionalization and biomolecule immobilization are readily accomplished. Triggered drug release allows the functionalized NDs to find their targets before the drugs are activated by local conditions. In this sense, the NDs are performing the well established role of postdrugs, smuggeling the inactive compound to their targets where they are released through bond cleavage.The objective of the proposed program concerns the fabrication of NDs modified with photo-label linkers where different molecules can be directly attached, without chemically modification of the biomolecule itself. In a proof of principle, horse radish peroxidase (HRP) will be linked to NDs modified with the photo-label o-nitrobenzyl group and the release followed by UV/Vis. In a later state the controlled release of drugs such as ibuprofen, adriamycin or antigens will be looked at.The proposed research project brings together centers from France, the UK, Spain and the Ukrain. The network offers training in the fabrication and characterization of new materials for biological applications. Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesengineering and technologynanotechnologynano-materials Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2010-IRSES - Marie Curie Action "International Research Staff Exchange Scheme" Call for proposal FP7-PEOPLE-2010-IRSES See other projects for this call Funding Scheme MC-IRSES - International research staff exchange scheme (IRSES) Coordinator UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE - LILLE I Address Cite scientifique 59655 Villeneuve d'ascq France See on map Activity type Higher or Secondary Education Establishments Administrative Contact Sabine Szunerits (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (4) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY OF BRIGHTON United Kingdom EU contribution € 47 500,00 Address Lewes road mithras house BN2 4AT Brighton See on map Region South East (England) Surrey, East and West Sussex Brighton and Hove Activity type Higher or Secondary Education Establishments Administrative Contact Peter Cragg (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITE DE PICARDIE JULES VERNE France EU contribution € 36 100,00 Address Chemin du thil 80025 Amiens See on map Region Hauts-de-France Picardie Somme Activity type Higher or Secondary Education Establishments Administrative Contact Veaceslav Grosu (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 20 900,00 Address Calle serrano 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Eusebio Jiménez Arroyo (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSIDAD DE SEVILLA Spain EU contribution € 15 200,00 Address Calle s. fernando 4 41004 Sevilla See on map Region Sur Andalucía Sevilla Activity type Higher or Secondary Education Establishments Administrative Contact Margarita Martinez-Pais Loscertales (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
