Objective
Associations between eukaryotes and microorganisms are frequently observed in nature. They are highly diverse and range along a continuum between parasitism and mutualism. Although numerous symbiotic associations have been well described at the phenotypic level, the mechanisms involved in the maintenance of the association and their evolutionary consequences are rarely studied. However, the presence of a permanent resident can have direct consequences on the host developmental program and immune system, and dramatically change the outcome of a secondary infection by a pathogen. As the oxidative environment is known to play pleiotropic roles in development and immunity, I propose to determine to what extent its control plays a role in the stability of symbiotic associations and in the evolution of both partners.
To address these issues, I plan to work on various symbiotic associations, differing in the characteristics of the symbiotic relationship. I will focus on two monospecific interactions between invertebrates and bacteria (Squid/Vibrio, Insect/Wolbachia), natural but easily examined systems for defining the biochemical/genetic events that underlie long-term infection by non-pathogenic bacteria. In each model system, I will first characterize the molecular mechanisms involved in the control of the oxidative environment, then determine how the oxidative environment varies in response to symbiosis, and finally assess to what extent its regulation affects the stability of the symbiosis. In particular, I propose to determine if: 1) the symbiont manipulates the host oxidative environment to favour its maintenance, 2) the host evolves to tolerate the presence of the symbiont, and 3) changes of the oxidative environment only constitute a by-product of the symbiotic association. Finally, the comparative analysis will allow me to determine potential shared mechanisms that play a key role in the maintenance of symbiotic associations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences evolutionary biology
- medical and health sciences basic medicine immunology
- natural sciences biological sciences biological behavioural sciences ethology biological interactions
- natural sciences biological sciences zoology invertebrate zoology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
69622 Villeurbanne Cedex
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.