Objective
The innate immune system provides the first line of immune defence against infectious diseases and in the fight against cancer. The direct recognition of bacteria, viruses and cancer cells by innate immune cells is crucial for priming of the adaptive immune response and the establishment of immunological memory.
Innate immune signalling pathways mediated by Toll-like receptors are quite well studied. Little is known about the activation of additional signalling pathways in innate immunity. This project aims at the identification of novel molecules in innate immune pathways in mammalian cells by functional genomics. The focus will be on signalling pathways in myeloid cells involving the Immunoreceptor Tyrosine-based Activation Motif (ITAM) containing adaptor DAP12 and additional innate immune signalling pathways.
These studies will include the identification and investigation of innate immune pathways in response to their natural ligands, bacteria and viruses. Powerful technologies of refined retroviral expression cloning combined with advanced proteomics will be applied to identify novel molecular targets by functional read-outs.
The molecules originating from the screens will be validated by gene over-expression and gene knock-down in primary immune cells and in in-vivo mouse models. These studies have the potential to increase the basic knowledge in innate immunity and to identify novel drug targets. Molecular targets for agonistic compounds might be identified to provide new anti-viral and anti-bacterial drugs to fight against emerging infectious diseases.
The screens might also discover molecular targets for antagonistic compounds for indications of inflammatory diseases and septic shock syndrome. The scientific expertise of the team leader and excellent facilities at the host organisation including a unit of technology transfer are essential prerequisites for the proposed excellence team 'innate immunity'.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences health sciences infectious diseases
- medical and health sciences basic medicine immunology
- medical and health sciences clinical medicine oncology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-8
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
HEIDELBERG
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.