Objective
"Archaea, forming the third domain of life, are extremely interesting to study because of their position between Bacteria and Eukaryotes. Indeed, they possess characteristics from these two other domains; they are morphologically very close to bacteria (cell size; absence of a nuclear envelope) but show cellular mechanisms closer to eukaryotic ones (DNA replication, histones). Following a bioinformatics study of replication genes environments in archaea, Pr. Forterre’s lab showed that 2 clusters were highly conserved among archaea; surprisingly, the clusters grouped genes coding for replisome AND ribosomal proteins. The conservation of the clusters throughout evolution strongly suggests a functional interaction of the proteins involved. This project aims at studying the clusters to uncover a coupling between replication and translation in archaea. This would bring tremendous results for two reasons: first, such a control has never been shown in archaea or eukaryotes before, and was discovered only recently in bacteria, through the stringent response. No mechanism is known in archaea and eukaryotes to link proteins synthesis to DNA synthesis. Second, most of the genes located in the clusters have homologues in eukaryotes, and some of them are overexpressed in some human cancers. Thus, finding a new function and interacting partners for these proteins would help in understanding their role in cancer development and defining new therapeutic targets."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences biological sciences genetics DNA
- natural sciences biological sciences biochemistry biomolecules proteins
- medical and health sciences clinical medicine oncology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
91405 ORSAY CEDEX
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.