Objective
Chronic lung disease is a very common cause of morbidity and mortality across Europe. For example, chronic obstructive pulmonary disease (COPD) causes over 30,000 deaths/year in the UK with a rising incidence and it is estimated that by 2020 COPD will become the third leading cause of death and the fifth leading cause of chronic disability worldwide. In the EU approximately 41,300 lost work days per 100’000 population are due to COPD while productivity losses amount to €28.5 billion annually and patient care totals €10.3 billion annually. To date, therapies to limit/reverse fibrosis in the lung have failed to provide long-term beneficial effects and new therapeutic targets are desperately needed. The work proposed in this application will allow me to investigate the role of the immune system in general, and more specifically the macrophage, in fibrosis and identify new therapeutic targets. The themes highlighted in this proposal complement priority areas identified within the FP7: Health program including Innovative therapeutic approaches and intervention and Translational research in major diseases. In this fellowship I will investigate the role of cellular immunity and in particular the macrophage in orchestrating the environment in the lung that determines the fibrotic response to injury. I will investigate whether specific macrophage phenotypes contribute to loss of function by driving aberrant epithelial repair and fibrotic remodeling in the lung. I hypothesis that manipulation of lung macrophage phenotype by treatment with azithromycin may limit fibrosis in the lung.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- social sciences sociology demography mortality
- medical and health sciences basic medicine immunology
- social sciences economics and business economics production economics productivity
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2010-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
NE1 7RU Newcastle Upon Tyne
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.