Objective Animal venoms are complex cocktails of peptides that have enormous potential as novel therapeutic leads. Replicating in vitro the diversity of venoms by generating large synthetic combinatorial peptide libraries will solve the challenge of working with limited amounts of natural products and permit high-throughput investigation of their pharmacology. A new investigation paradigm associating transcriptomics and proteomics is the only way to achieve this goal and to address the complexity of this unexplored 40,000,000 peptide resource. The vision of the VENOMICS project is to develop, integrate and implement cutting-edge and innovative technologies in a high-throughput approach to investigate the enormous structural and pharmacological diversity of venom peptides. We will use the largest venom and venom gland collection in the world to generate a comprehensive sequence database of bioactive peptides, and produce a 10,000 reticulated peptide bank to be used in drug discovery efforts and development of novel therapeutics. A 1000-fold improvement in throughput over the current situation (1 to 2 candidates generated per year) is reasonably foreseen.Implementation of the project will require both improvements and the integration of exisiting technologies in a high-throughput workflow comprising venom and tissue sourcing, mass spectrometry-based automated de novo peptide sequencing, transcriptomics of venom gland-derived RNA or cDNA/EST libraries, bioinformatics, implementation of a sequence database, and highly parallel synthetic or recombinant production including peptide refolding. The last step will be the validation of the approach in functional assays targeting specific pathologies. VENOMICS is a high-impact project with societal (new drugs against life threatening diseases), scientific and technological (filling the drug discovery pipeline), political (European leadership in the field) and economic (new opportunities for the biologics market) benefits. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacydrug discoverynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsproteomicsnatural sciencescomputer and information sciencesdatabasesmedical and health sciencesbasic medicinepathologynatural sciencesbiological sciencesgeneticsRNA Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.1.1-1 - SME-targeted research for developing tools and technologies for high-throughput research Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES Address Rue leblanc 25 75015 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Nicolas Gilles (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution € 1 319 885,36 Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE DE LA MEDITERRANEE D'AIX-MARSEILLE II Participation ended France EU contribution € 1 280,38 Address Boulevard charles livon, jardin du pharo 58 13284 Marseille See on map Activity type Higher or Secondary Education Establishments Administrative Contact Celine Damon (Ms.) Links Contact the organisation Opens in new window Website Opens in new window VENOMETECH SAS Participation ended France EU contribution € 373 912,96 Address Route des dolines 473 villa 3 06560 Valbonne See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Pierre Escoubas (Dr.) Links Contact the organisation Opens in new window Website Opens in new window SISTEMAS GENOMICOS SL Spain EU contribution € 1 185 049,60 Address Ronda g marconi - parque tecnologico de valencia 6 46980 Paterna See on map Region Este Comunitat Valenciana Valencia/València Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Rebeca Miñambres Herráiz (Dr.) Links Contact the organisation Opens in new window Website Opens in new window NZYTECH LDA Portugal EU contribution € 737 800,00 Address Estrada do paco do lumiar campus do lumiar edificio e - r/c 1649 038 Lisboa See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Carlos Fontes (Prof.) Links Contact the organisation Opens in new window Website Opens in new window ABSISKEY CP France EU contribution € 159 000,00 Address Rue colonel dumont 26 38000 Grenoble See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Olivier De Bardonneche (Mr.) Links Contact the organisation Opens in new window Website Opens in new window ZEALAND PHARMACEUTICALS AS Denmark EU contribution € 344 400,00 Address Smedeland 36 2600 Glostrup See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Cristian Grøndahl (Dr.) Links Contact the organisation Opens in new window Website Opens in new window UNIVERSITE D'AIX MARSEILLE France EU contribution € 836 887,35 Address Boulevard charles livon 58 le pharo 13284 Marseille See on map Region Provence-Alpes-Côte d’Azur Provence-Alpes-Côte d’Azur Bouches-du-Rhône Activity type Higher or Secondary Education Establishments Administrative Contact Céline Damon (Ms.) Links Contact the organisation Opens in new window UNIVERSITE DE LIEGE Belgium EU contribution € 1 040 571,00 Address Place du 20 aout 7 4000 Liege See on map Region Région wallonne Prov. Liège Arr. Liège Activity type Higher or Secondary Education Establishments Administrative Contact Edwin De Pauw (Prof.) Links Contact the organisation Opens in new window Website Opens in new window KATHOLIEKE UNIVERSITEIT LEUVEN Participation ended Belgium EU contribution € 0,00 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Myriam Witvrouw (Dr.) Links Contact the organisation Opens in new window Website Opens in new window
