CORDIS
EU research results

CORDIS

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Novel approaches for prevention and degeneration of pathogenic bacteria biofilms formed on medical devices e.g. catheters

Project information

Grant agreement ID: 278402

Status

Closed project

  • Start date

    1 January 2012

  • End date

    31 December 2014

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 933 882,05

  • EU contribution

    € 2 971 045

Coordinated by:

UNIVERSITAET FUER BODENKULTUR WIEN

Austria

Objective

Biofilms are bacterial communities encased in a self-produced hydrated polymeric matrix. An important characteristic of microbial biofilms is their innate resistance to the immune system and susceptibility to antibiotics. This resistance has made microbial biofilms a common cause of medical infections, and difficult-to-treat infections caused by colonized foreign bodies.
The NOVO project aims at developing novel approaches to prevent and/or degrade biofilms on catheters elongating their usage in humans up to 10 days.
Two complementary approaches for biofilm prophylaxis will be developed:
A. Ultrasonic coating of Inorganic antibiofouling agents (process developed by partner BIU) based on a single step sonochemical process to: a) Produce metal fluorides or metal oxides (e.g. MgF2, ZnO) nanoparticles (NPs) and simultaneously b) Impregnate them as antibacterial factors on the catheters. c) Co-coating with bio-inert polymer layers (containing highly hydrophilic antifouling polyethylene glycol, zwitterionic moieties or sugar-groups) grafted onto NPs of adjusted size to the size of MgF2/ZnO NPs or directly onto MgF2/ZnO NPs; to form a hydrogel layer for the protection of the MgF2/ZnO antibiofouling activity.
B. Bio/organic antibiofouling activation: 1) Novel coating for catheters based on radical catalyzed polymers to yield anti-bacterial activity. An enzymatic reaction will be applied on the phenolic compounds to generate phenolic radicals to be further polymerized on the catheter surface as an antibiofilm agent. 2) Develop and engineer Cellobiose Dehydrogenases (CDH) that actively oxidizes and degrades biofilms polysaccharides concomitantly producing stoichiometrically H2O2 as antibacterial agent. The enzymes will be coated on the catheters via a lubricant or by the Ultrasonic (US) process after their immobilization. Some novel CDH representatives already show very low activity on glucose which should be removed by further genetic engineering.

Coordinator

UNIVERSITAET FUER BODENKULTUR WIEN

Address

Gregor Mendel Strasse 33
1180 Wien

Austria

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 405 402,38

Administrative Contact

Georg Guebitz (Prof.)

Participants (11)

BAR ILAN UNIVERSITY

Israel

EU Contribution

€ 399 740

UNIVERSITAT POLITECNICA DE CATALUNYA

Spain

EU Contribution

€ 268 245

UNIVERSITAET DUISBURG-ESSEN

Germany

EU Contribution

€ 276 000

MULTIPROFILE HOSPITAL FOR ACTIVE TREATMENT AND EMERGENCY MEDECINE PIROGOV

Bulgaria

EU Contribution

€ 123 960

SYNOVO GMBH

Germany

EU Contribution

€ 316 800

ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO

Portugal

EU Contribution

€ 280 800

DI DR ANDREAS PAAR KG

Austria

EU Contribution

€ 299 870

PRONEFRO - PRODUTOS NEFROLOGICOS SA

Portugal

EU Contribution

€ 164 240

DEGANIA SILICONE LTD

Israel

EU Contribution

€ 182 700

OSM-DAN LTD

Israel

EU Contribution

€ 219 410

TECHNISCHE UNIVERSITAET GRAZ

Austria

EU Contribution

€ 33 877,62

Project information

Grant agreement ID: 278402

Status

Closed project

  • Start date

    1 January 2012

  • End date

    31 December 2014

Funded under:

FP7-HEALTH

  • Overall budget:

    € 3 933 882,05

  • EU contribution

    € 2 971 045

Coordinated by:

UNIVERSITAET FUER BODENKULTUR WIEN

Austria