Objective Biofilms are bacterial communities encased in a self-produced hydrated polymeric matrix. An important characteristic of microbial biofilms is their innate resistance to the immune system and susceptibility to antibiotics. This resistance has made microbial biofilms a common cause of medical infections, and difficult-to-treat infections caused by colonized foreign bodies.The NOVO project aims at developing novel approaches to prevent and/or degrade biofilms on catheters elongating their usage in humans up to 10 days.Two complementary approaches for biofilm prophylaxis will be developed:A. Ultrasonic coating of Inorganic antibiofouling agents (process developed by partner BIU) based on a single step sonochemical process to: a) Produce metal fluorides or metal oxides (e.g. MgF2, ZnO) nanoparticles (NPs) and simultaneously b) Impregnate them as antibacterial factors on the catheters. c) Co-coating with bio-inert polymer layers (containing highly hydrophilic antifouling polyethylene glycol, zwitterionic moieties or sugar-groups) grafted onto NPs of adjusted size to the size of MgF2/ZnO NPs or directly onto MgF2/ZnO NPs; to form a hydrogel layer for the protection of the MgF2/ZnO antibiofouling activity.B. Bio/organic antibiofouling activation: 1) Novel coating for catheters based on radical catalyzed polymers to yield anti-bacterial activity. An enzymatic reaction will be applied on the phenolic compounds to generate phenolic radicals to be further polymerized on the catheter surface as an antibiofilm agent. 2) Develop and engineer Cellobiose Dehydrogenases (CDH) that actively oxidizes and degrades biofilms polysaccharides concomitantly producing stoichiometrically H2O2 as antibacterial agent. The enzymes will be coated on the catheters via a lubricant or by the Ultrasonic (US) process after their immobilization. Some novel CDH representatives already show very low activity on glucose which should be removed by further genetic engineering. Fields of science medical and health sciencesmedical biotechnologygenetic engineeringnatural scienceschemical sciencespolymer sciencesmedical and health sciencesbasic medicineimmunologyengineering and technologymaterials engineeringcoating and filmsmedical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsantibiotics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.3.1-5 - Development of tools to control microbial biofilms with relevance to clinical drug resistance Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITAET FUER BODENKULTUR WIEN Address Gregor mendel strasse 33 1180 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Georg Guebitz (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all BAR ILAN UNIVERSITY Israel EU contribution € 399 740,00 Address Bar ilan university campus 52900 Ramat gan See on map Activity type Higher or Secondary Education Establishments Administrative Contact Estelle Waise (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAT POLITECNICA DE CATALUNYA Spain EU contribution € 268 245,00 Address Calle jordi girona 31 08034 Barcelona See on map Region Este Cataluña Barcelona Activity type Higher or Secondary Education Establishments Administrative Contact Cristina Costa (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAET DUISBURG-ESSEN Germany EU contribution € 276 000,00 Address Universitatsstrasse 2 45141 Essen See on map Region Nordrhein-Westfalen Düsseldorf Essen, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Kirsten Gercek (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MULTIPROFILE HOSPITAL FOR ACTIVE TREATMENT AND EMERGENCY MEDECINE PIROGOV Bulgaria EU contribution € 123 960,00 Address Totleben blvd 21 1606 Sofia See on map Activity type Research Organisations Administrative Contact Aneta Hubenova (Prof.) Links Contact the organisation Opens in new window Other funding No data SYNOVO GMBH Germany EU contribution € 316 800,00 Address Paul ehrlich str 15 72076 Tuebingen See on map Region Baden-Württemberg Tübingen Tübingen, Landkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Michael Burnet (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO Portugal EU contribution € 280 800,00 Address Campus de azurem universidade do minho 4800 058 Guimaraes See on map Region Continente Norte Ave Activity type Other Administrative Contact Artur Cavaco (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DI DR ANDREAS PAAR KG Austria EU contribution € 299 870,00 Address Leechgasse 55/8 8010 Graz See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Andreas Paar (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PRONEFRO - PRODUTOS NEFROLOGICOS SA Portugal EU contribution € 164 240,00 Address Rua b - sector vii lote 98 4470-436 Maia See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Assunção Assunção Mascarenhas (Ms.) Links Contact the organisation Opens in new window Other funding No data DEGANIA SILICONE LTD Israel EU contribution € 182 700,00 Address Kibbutz degania bet 15130 Kibbutz degania b See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Oded Stein (Mr.) Links Contact the organisation Opens in new window Other funding No data OSM-DAN LTD Israel EU contribution € 219 410,00 Address 19 pro neeman yuval st 7608665 Rehovot See on map Administrative Contact Pnina Dan (Dr.) Links Contact the organisation Opens in new window Other funding No data TECHNISCHE UNIVERSITAET GRAZ Participation ended Austria EU contribution € 33 877,62 Address Rechbauerstrasse 12 8010 Graz See on map Region Südösterreich Steiermark Graz Activity type Higher or Secondary Education Establishments Administrative Contact Michaela Pressnig (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
