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Biohybrid templates for peripheral nerve regeneration

Objective

The BIOHYBRID consortium was build up with the overall aim to develop, in a preclinical perspective, an innovative biohybrid artificial nerve device for the regenerative treatment of traumatic injuries of peripheral nerves. This consortium consists of three active and well integrated SMEs as well as seven academic partners that are recognised leaders in the scientific areas of interest for this project. Furthermore, another partner has substantiated expertises to meet the regulatory work for ATMP development.
Traumatic injuries of peripheral nerves represent a major cause for morbidity and morbility
in Europe and their social impact is considerably high. It has been estimated that the incidence of peripheral nerve injuries derived from trauma is about 300,000 cases per year. Moreover, nerve injuries are an important component of traumatic limb amputations, with an incidence of 2/100,000 persons per year described for hand amputations. Therefore, repair and regeneration of peripheral nerve injuries represent a major field where clinical application of innovative therapies in regenerative medicine should be sought.
Peripheral nerve fibers are able to regenerate and lead to functional recovery provided that an
appropriate milieu and guide is available. However, the clinical outcome of neural repair after
extended substance loss after nerve injury is often unsatisfactory and therefore innovative strategies for improving the outcome after neural damage are in demand.
The main objective of the BIOHYBRID project is the development of a regenerative therapy using an innovative biohybrid artificial nerve device with the goal of repairing damaged nerve trunks. The work program includes an integrated experimental approach bringing together the main aspects of regenerative medicine: a) reconstructive microsurgery, b) regenerative scaffolds and c) transplantation. This approach will allow the biological pre-fabrication of biohybrid nerve devices, their transplantation into nerve gaps in various animal models and the comprehensive evaluation of the regenerative outcome. The SME involvement, for the first time in this biomedical field, will not be limited to production and supply of materials and services but includes also active participation in the conduction of the experiments for in vivo preclinical assessment and follow-up. Based on the extensive basic and clinical experience within this consortium a biohybrid artificial nerve device will be developed together with standardised application and evaluation parameters. A key objective of this study will be to generate, for the first time, a protocol that can serve as a template for future clinical trials in the regenerative therapy of damaged peripheral nerves. The BIOHYBRID project with its consortium partners combines excellent expertise to successfully reach the objectives and stands therfore on the front line of regenerative medicine approaches.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

MEDIZINISCHE HOCHSCHULE HANNOVER
Address
Carl-neuberg-strasse 1
30625 Hannover
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 977 600
Administrative Contact
Frank Dittrich (Mr.)

Participants (9)

UNIVERSIDAD AUTONOMA DE BARCELONA
Spain
EU contribution
€ 472 400
Address
Calle Campus Universitario Sn Cerdanyola V
08290 Cerdanyola Del Valles
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Francisca Rabadán Sotos (Ms.)
MAX IV Laboratory, Lund University
Sweden
EU contribution
€ 400 400
Address
Paradisgatan 5C
22100 Lund
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anneli Wiklander (Ms.)
UNIVERSIDADE DO MINHO
Portugal
EU contribution
€ 400 400
Address
Largo Do Paco
4704 553 Braga
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Vasco Teixeira (Mr.)
THE FOUNDATION FOR MEDICAL RESEARCH INFRASTRUCTURAL DEVELOPMENT AND HEALTH SERVICES NEXT TO THE MEDICAL CENTER TEL AVIV
Israel
EU contribution
€ 400 400
Address
Weizmann Street 6
64239 Tel Aviv
Activity type
Research Organisations
Administrative Contact
Michal Roll (Dr.)
UNIVERSITA DEGLI STUDI DI TORINO
Italy
EU contribution
€ 508 400
Address
Via Giuseppe Verdi 8
10124 Torino
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Alessandro De Filippo (Dr.)
N.V.R RESEARCH LTD
Israel
EU contribution
€ 1 002 400
Address
Haharash Street 17
74031 Ness Ziona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Abraham Shahar (Prof.)
MEDOVENT GMBH
Germany
EU contribution
€ 1 250 400
Address
Friedrich Koenig Strasse 3
55130 Mainz
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Susanne Krick (Ms.)
ALTAKITIN SA
Portugal
EU contribution
€ 502 400
Address
Rua Joao Francisco Do Casal, Armazem 4, Zona Industrial De Taboeira
3800 266 Aveiro
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Miguel Martinha (Dr.)
KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN
Germany
EU contribution
€ 7 200
Address
Ismaninger Strasse 22
81675 Muenchen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Renate Rädlein