Skip to main content

Biomarker for Cardiovascular Risk Assessment in Europe

Objective

Biomarkers are considered as tools to enhance cardiovascular risk estimation. However, the value of biomarkers on risk estimation beyond European risk scores, their comparative impact among different European regions and their role in the drive towards personalised medicine remains uncertain.

Based on harmonised and standardised European population cohorts we have built significant research collaboration, expertise and infrastructure in the EU. We will apply highly innovative SME-driven technologies and perform large-scale biomarker determination to assess the predictive value of existing and emerging biomarkers.

Selection of emerging biomarkers will be based on integrated cutting-edge quantitative proteomic, transcriptomic, metabolomic, and miRNomic datasets established by private and public consortium members that will be disclosed to this consortium. Existing biomarkers will be selected based on non-redundancy and their association with cardiovascular risk and phenotypes. After SME-guided development of innovative assay systems biomarkers will be tested and validated in a stepwise fashion among European populations in primary and secondary prevention. In addition to their impact on risk prediction, their association with lifestyle determinants and cardiovascular phenotypes assessed by ultrasound and MRI technique will be evaluated.

We will establish a BiomarCaRE panel which leads to improved disease prediction among different European populations. International collaborations with world-class clinical trial investigators will add data on the interaction of the BiomarCaRE panel with risk-lowering medication and lifestyle changes. The outcome of SME-driven technology development and clinical validation will undergo a medical technology assessment. The determination of cost-effectiveness will guide further clinical evaluation. These studies will reveal new methods of improved cardiovascular risk estimation and will open the path towards personalised medicine.

Field of science

  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug
  • /natural sciences/physical sciences/acoustics/ultrasound

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF
Address
Martinistrasse 52
20251 Hamburg
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 255 925
Administrative Contact
Tanja Zeller (Dr.)

Participants (29)

TERVEYDEN JA HYVINVOINNIN LAITOS
Finland
EU contribution
€ 737 440
Address
Mannerheimintie 166
00271 Helsinki
Activity type
Research Organisations
Administrative Contact
Kari Kuulasmaa (Prof.)
CAVADIS BV
Netherlands
EU contribution
€ 867 880
Address
Catharijnesingel 52
3511 GC Utrecht
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Heico Breek (Dr.)
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
EU contribution
€ 105 780
Address
Heidelberglaan 100
3584 CX Utrecht
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerard Pasterkamp (Prof.)
HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany
EU contribution
€ 52 320
Address
Ingolstadter Landstrasse 1
85764 Neuherberg
Activity type
Research Organisations
Administrative Contact
Jürgen Ertel (Dr.)
BIOCRATES LIFE SCIENCES AG
Austria
EU contribution
€ 372 560
Address
Eduard Bodem Gasse 8 1 Stock
6020 Innsbruck
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Markus Speiser (Dr.)
UNIVERSITAET zu LUEBECK
Germany
EU contribution
€ 266 700
Address
Ratzeburger Allee 160
23562 Lubeck
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gabriele Schatton
UMIT- PRIVATE UNIVERSITAT FUER GESUNDHEITSWISSENSCHAFTEN, MEDIZINISCHEINFORMATIK UND TECHNIK GMBH
Austria
EU contribution
€ 148 080
Address
Eduard Wallnoefer - Zentrum 1
6060 Hall In Tirol
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Petra Schnell-Inderst (Dr.)
MEDIZINISCHE HOCHSCHULE HANNOVER
Germany
EU contribution
€ 110 000
Address
Carl-neuberg-strasse 1
30625 Hannover
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Dittrich (Mr.)
FLEET BIOPROCESSING LIMITED
United Kingdom
EU contribution
€ 576 800
Address
Pale Lane Pale Lane Farm Unit 6
RG27 8DH Hartley Wintney Hants
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Adrian Wilkinson (Dr.)
BIOCARTIS SA

Participation ended

Switzerland
EU contribution
€ 291 890
Address
Epfl Quartier De L Innovation - Building G
1015 Lausanne
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Patrick Van Den Bogaard (Dr.)
RESEARCH NETWORK SERVICES LIMITED
United Kingdom
EU contribution
€ 240 000
Address
St John Street 145-157 2Nd Floor
EC1V 4PY London
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Erik Werner (Dr.)
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ
Germany
EU contribution
€ 57 876
Address
Langenbeckstrasse 1
55131 Mainz
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Uta Veith (Dr.)
UNIVERSITETET I TROMSOE - NORGES ARKTISKE UNIVERSITET
Norway
EU contribution
€ 84 084
Address
Hansine Hansens Veg 14
9019 Tromso
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Anne Fismen (Ms.)
UNIVERSITA CATTOLICA DEL SACRO CUORE
Italy
EU contribution
€ 56 212
Address
Largo Gemelli 1
20123 Milano
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Filippo Leone (Mr.)
UNIVERSITAET GREIFSWALD
Germany
EU contribution
€ 67 376
Address
Domstrasse 11
17489 Greifswald
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Andrea Völker (Dr.)
University College London
United Kingdom
EU contribution
€ 81 136
Address
Gower Street
WC1E 6BT London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Gerta Borg-Carbott (Ms.)
THE QUEEN'S UNIVERSITY OF BELFAST
United Kingdom
EU contribution
€ 55 910
Address
University Road Lanyon Building
BT7 1NN Belfast
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Colleen Spence (Ms.)
INSTITUT PASTEUR DE LILLE FONDATION
France
EU contribution
€ 53 945
Address
Rue Du Professeur Calmette 1
59019 Lille
Activity type
Research Organisations
Administrative Contact
Fabienne Jean (Dr.)
Consorci Institut Catala de Ciències Cardiovasculars
Spain
EU contribution
€ 30 310
Address
Av. Santantoni M. Claret
08025 Barcelona
Activity type
Research Organisations
Administrative Contact
Joaquim Escobar (Mr.)
UMEA UNIVERSITET
Sweden
EU contribution
€ 48 703
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Lars Wikman (Mr.)
TARTU ULIKOOL
Estonia
EU contribution
€ 74 911
Address
Ulikooli 18
51005 Tartu
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Merike Leego (Ms.)
REGION HOVEDSTADEN
Denmark
EU contribution
€ 63 773
Address
Kongens Vaenge 2
3400 Hillerod
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Gitte Fogelberg (Ms.)
UNIVERSITA DEGLI STUDI DELL'INSUBRIA
Italy
EU contribution
€ 75 239
Address
Via Ravasi 2
21100 Varese
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Giovanni Barbieri (Dr.)
UNIVERSITY OF DUNDEE
United Kingdom
EU contribution
€ 68 523
Address
Nethergate
DD1 4HN Dundee
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Jim Mcgregor (Mr.)
UNIVERSITATSSPITAL BASEL
Switzerland
EU contribution
€ 39 858
Address
Hebelstrasse 32
4031 Basel
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
Administrative Contact
Thomas Gruberski (Dr.)
UNIVERSITAET ULM
Germany
EU contribution
€ 46 418
Address
Helmholtzstrasse 16
89081 Ulm
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Frank Gleixner (Mr.)
HAMILTON HEALTH SCIENCES CORPORATION

Participation ended

Canada
Address
1280 Main Street West
L8S 4L8 Hamilton
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Beena Cracknell (Ms.)
THE UNIVERSITY OF SYDNEY
Australia
EU contribution
€ 51 324
Address
Camperdown Campus Arundel St 71/79
2006 Sydney
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kate Taylor (Ms.)
INSTITUTO NEUROLOGICO MEDITERRANEO- NEUROMED SRL
Italy
EU contribution
€ 19 027
Address
Via Atinense 18
86077 Pozzilli Is
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Emilia Belfiore (Dr.)