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New Technologies and Production Tools for Complex Protein Biologics

Objective

ComplexINC conceptualizes and systematically generates advanced tool-kits to enable high-throughput assembly of complex biologics and metabolic pathways in eukaryotic expression systems, for micro- to large scale production of high-quality protein specimens for drug discovery and as bio-therapeutics. Essential parts of these tool-kits will be innovative next-generation HT DNA assembly pipelines for automated multigene expression construct generation, a superior synthetic viral genome, genetically engineered animal and yeast cell lines with unique capabilities with respect to protein maturation and modification, as well as advanced methods for bioprocessing and integrated quality control. Putting these tools and production technologies in place will have a dramatic impact on the availability of challenging proteins and protein complexes including such of human origin, with tailor-made properties specifically geared towards their application in drug discovery and in the treatment of human diseases. The superior next generation technology platforms created within ComplexINC, the generated IP, protein targets and therapeutics will be commercially exploited, and serve as a nucleus to initiate a new start-up enterprise to commercialize high-end biologics discovery and production.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

EUROPEAN MOLECULAR BIOLOGY LABORATORY
Address
Meyerhofstrasse 1
69117 Heidelberg
Germany
Activity type
Research Organisations
EU contribution
€ 1 037 652,80
Administrative Contact
Sonja Noss (Ms.)

Participants (7)

CRELUX GMBH
Germany
EU contribution
€ 1 330 366
Address
Am Klopferspitz 19A
82152 Martinsried
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ismail Moarefi (Dr.)
HELMHOLTZ-ZENTRUM FUR INFEKTIONSFORSCHUNG GMBH
Germany
EU contribution
€ 752 852
Address
Inhoffenstrasse 7
38124 Braunschweig
Activity type
Research Organisations
Administrative Contact
Michael Straetz (Dr.)
INSTITUTO DE BIOLOGIA EXPERIMENTAL E TECNOLOGICA
Portugal
EU contribution
€ 1 064 560
Address
Avenida Da Republica Quinta Do Marques
2781-901 Oeiras
Activity type
Research Organisations
Administrative Contact
Elsa Vieira (Ms.)
AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 716 012
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jiménez Arroyo (Mr.)
BIOINGENIUM SL
Spain
EU contribution
€ 654 320
Address
Baldiri Reixac 15
08028 Barcelona
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ramon Ramon (Dr.)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 316 600
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Hannah Weber (Ms.)
GBIOTECH SARL
Switzerland
EU contribution
€ 127 320
Address
Chemin Des Aulx 14
1228 Plan Les Ouates
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Daniel Fitzgerald (Dr.)