Objective "About 75% of advanced epithelial ovarian cancer (EOC) patients respond to first-line surgery and chemotherapy but most relapse and ultimately acquire platinum resistance which soon leads to death. Relapsed high grade serous ovarian cancer (HGSOC) is the single main cause of EOC-related morbidity and mortality (despite the fact that HGSOC is highly chemosensitive). We hypothesize that the primary tumour includes a small population of resistant cells that are ultimately responsible for relapse and that by targeting this population front-line we may prolong disease-free survival or even achieve cure. OCTIPS will use unique retrospective and novel prospective paired tumour samples collected at the time of diagnosis and relapse to identify and validate molecules and pathways responsible for relapse. This identification will employ cutting edge high throughput multiplatform analyses such as next generation sequencing, mRNA and miRNA expression arrays and SNP array. Known and newly defined molecules or pathways will be evaluated in innovative integrated cancer model systems, utilising cell lines and avian egg and murine xenografts. New therapies to target these molecules and pathways will be developed and validated in these model systems. In order to translate these findings into patient benefit, agents that target the relapsing cell population will be tested for tolerability, efficacy, ability to combine with first line chemotherapy and then in randomised first line trials by the OCTIPS consortium.By translating the clinical observation of treatment failures into innovative cancer models that mimic relapsed ovarian cancer, we will validate improved front-line therapeutic strategies to help prolong patient survival. The impact of this application is that it defines a highly rigorous approach to integrate the bedside to bench to bedside paradigm, leading to novel prognosis-changing strategies for the treatment of ovarian cancer patients." Fields of science social sciencessociologydemographymortalitymedical and health sciencesclinical medicinesurgerynatural scienceschemical sciencesinorganic chemistrytransition metalsmedical and health sciencesclinical medicineoncology Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.4.1-2 - Translational research on cancers with poor prognosis Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator MEDIZINISCHE UNIVERSITAET WIEN Address Spitalgasse 23 1090 Wien Austria See on map Region Ostösterreich Wien Wien Activity type Higher or Secondary Education Establishments Administrative Contact Dan Cacsire Casstillo-Tong (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (10) Sort alphabetically Sort by EU Contribution Expand all Collapse all CHARITE - UNIVERSITAETSMEDIZIN BERLIN Germany EU contribution € 241 368,00 Address Chariteplatz 1 10117 Berlin See on map Region Berlin Berlin Berlin Activity type Higher or Secondary Education Establishments Administrative Contact Eveline Fräßdorf (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 433 000,00 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Tine Heylen (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom EU contribution € 324 045,40 Address South kensington campus exhibition road SW7 2AZ London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Administrative Contact Tatjana Palalic (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE UNIVERSITY OF EDINBURGH United Kingdom EU contribution € 285 752,00 Address Old college, south bridge EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Administrative Contact Valerie Renton (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data EMERGENTEC BIODEVELOPMENT GMBH Austria EU contribution € 230 986,00 Address Gersthofer strasse 29-31 1180 Vienna See on map Region Ostösterreich Wien Wien Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bernd Mayer (Dr.) Links Contact the organisation Opens in new window Other funding No data ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Netherlands EU contribution € 334 561,38 Address Dr molewaterplein 40 3015 GD Rotterdam See on map Region West-Nederland Zuid-Holland Groot-Rijnmond Activity type Higher or Secondary Education Establishments Administrative Contact Arjan P Bandel (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE France EU contribution € 291 012,00 Address Rue de tolbiac 101 75654 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Vincent Boyer (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INNOVO MIMETICS LIMITED Israel EU contribution € 149 360,00 Address Palmach suite 2 68 92587 Jerusalem See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Jonathan Goldstein (Mr.) Links Contact the organisation Opens in new window Other funding No data ALCEDIS GMBH Germany EU contribution € 60 300,00 Address Winchesterstrasse 2 35394 Giessen See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Elke Heidrich-Lorsbach (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data CYCLACEL LIMITED United Kingdom EU contribution € 115 425,00 Address James lindsay place unit 1 DD1 5JJ Dundee See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact David Blake (Dr.) Links Contact the organisation Opens in new window Other funding No data
