Objective The number of individuals with obesity and type 2 diabetes mellitus (T2DM) is increasing. An alarming aspect is decline in age of onset of T2DM, which is coupled to rise in childhood obesity. Accentuated insulin secretion is observed early in young obese individuals. In many subjects insulin hypersecretion is evident when insulin sensitivity is essentially normal. Based on these observations we propose insulin hypersecretion as an etiological factor promoting lipid deposition, insulin resistance, cellular dysfunction and death in insulin-producing beta-cells and insulin-target brown adipocytes. Pharmacology-based treatment strategies are limited for this growing patient group and the aim of the proposal is to identify novel strategies reducing insulin hypersecretion, which has not been considered a target for intervention in young obese individuals. To address the issue, pediatric obesity clinics and academic centres with focus on beta-cell biology, brown adipocyte imaging, transcript and protein profiling, genetics, epidemiology and bioinfomatics have formed a consortium with two SMEs specialized on biomarker discovery and clinical trials and one large drug company. In the project well-characterized European patient cohorts of more than 3000 obese children will be further characterized with regard to insulin secretion and brown adipocyte mass. Currently used drugs and new principles of intervention based on novel genes, idenitifed in the project and linked with insulin hypersecretion, will be examined for effects on insulin hypersecretion in translational work including the young obese subjects and isolated human islets. Following comprehensive analysis candidate compounds/principles attenuating insulin hypersecretion will be selected, from which novel therapeutic strategies are expected to emerge. Such therapeutic strategies will be of importance for afflicted individuals and European health economy and lead to new opportunities for European industry. Fields of science natural sciencesbiological sciencesgeneticsmedical and health scienceshealth sciencespublic healthepidemiologymedical and health sciencesclinical medicineendocrinologydiabetesnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health scienceshealth sciencesnutritionobesity Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.4.3-2 - Development of novel treatment strategies based on knowledge of cellular dysfunction Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UPPSALA UNIVERSITET Address Von kraemers alle 4 751 05 Uppsala Sweden See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Anders Alderborn (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (11) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITE DU LUXEMBOURG Luxembourg EU contribution € 380 800,00 Address 2 avenue de l'universite 4365 Esch-sur-alzette See on map Region Luxembourg Luxembourg Luxembourg Activity type Higher or Secondary Education Establishments Administrative Contact Eric Tschirhart (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PARACELSUS MEDIZINISCHE PRIVATUNIVERSITAT SALZBURG - PRIVATSTIFTUNG Austria EU contribution € 110 400,00 Address Strubergasse 21 5020 Salzburg See on map Region Westösterreich Salzburg Salzburg und Umgebung Activity type Higher or Secondary Education Establishments Administrative Contact Vera Coreth (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE United Kingdom EU contribution € 350 400,00 Address Trinity lane the old schools CB2 1TN Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Higher or Secondary Education Establishments Administrative Contact Renata Schaeffer (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAET LEIPZIG Germany EU contribution € 740 600,00 Address Ritterstrasse 26 04109 Leipzig See on map Region Sachsen Leipzig Leipzig Activity type Higher or Secondary Education Establishments Administrative Contact Gerhard Fuchs (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITE DE GENEVE Switzerland EU contribution € 546 266,80 Address Rue du general dufour 24 1211 Geneve See on map Region Schweiz/Suisse/Svizzera Région lémanique Genève Activity type Higher or Secondary Education Establishments Administrative Contact Jean-Charles Sanchez (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PROTEOSYS AG Participation ended Germany EU contribution € 160 981,50 Address Carl zeissstrasse 51 55129 Mainz See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Bernd Matuschek (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ASTRAZENECA UK LIMITED United Kingdom EU contribution € 0,00 Address 1 francis crick avenue cambridge biomedical campus CB2 0AA Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Li Wang (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data REGION UPPSALA Sweden EU contribution € 311 799,60 Address Po box 602 751 25 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Administrative Contact Sven-Arne Åsman (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SCANDINAVIAN CRO AB Sweden EU contribution € 244 800,00 Address Kungsgatan 41 753 21 Uppsala See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ulrika Hammarström Lüllmaa (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PIVOT BIOMEDICAL SCIENCE GMBH Germany EU contribution € 269 690,40 Address Max-planck-strasse 17 54296 Trier See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Mike Otto (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data GEMEINNUTZIGE SALZBURGER LANDESKLINIKEN BETRIEBSGESELLSCHAFT Austria EU contribution € 372 600,00 Address Mullner hauptstrasse 48 5020 Salzburg See on map Region Westösterreich Salzburg Salzburg und Umgebung Activity type Other Administrative Contact Christoph Mandlier (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
