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Mechanisms of prevention of type 2 diabetes by lifestyle intervention in subjects with pre-diabetes or at high-risk for progression

Objective

Type 2 diabetes (T2DM) is preventable by sustained changes in diet and physical exercise. Despite this, modern societies are already approaching 10% population prevalence of diabetes, and another 15% with pre-diabetes. The costs of T2DM are huge, approaching 10% of all health costs. Prevention of diabetes is a priority for national healthcare agencies and for the health insurance industry. Investment in prevention and lifestyle programmes requires a solid evidence-base for targeting and customising these interventions in a cost-effective manner. Translation of the findings from T2DM prevention studies to the benefit of general public health has not yet been possible.
DEXLIFE will identify novel diagnostic and predictive biomarkers (i) to detect the progression toward diabetes in high risk individuals and (ii) that are responsive to lifestyle interventions known to be effective in diabetes prevention. New biomarkers alone will be insufficient to alter the course of diabetes progression. We bring a strong translational focus to this proposal, by setting the main intervention in the real-life context of a major health insurance system. The accumulated phenotyping repertoire from an extensive panel of –omic analyses will be refined and modelled into a new diagnostic panel for the allocation of high risk subjects to individualised preventive regimens.
Our multi-disciplinary team has a strong track record in clinical diabetes and metabolism. Several unique clinical cohorts will provide the basis for a series of clinical, physiological and mechanistic investigations, which will identify, monitor and analyse the impact of biomarkers over time. An exercise and dietary intervention study will be included in two specific cohorts, enabling us to assess the impact of such interventions on plasma biomarkers and functional tissue-based markers. Project clinical and industry partners will support the translation of our findings into clinical practice.

Call for proposal

FP7-HEALTH-2011-two-stage
See other projects for this call

Coordinator

NOVO NORDISK INVEST 4 A/S
Address
Novo Alle 1
2880 Bagsvaerd
Denmark
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EU contribution
€ 942 495,57
Administrative Contact
John Nolan (Prof.)

Participants (9)

DUBLIN CITY UNIVERSITY
Ireland
EU contribution
€ 905 443,60
Address
Glasnevin
9 Dublin
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Donal O'gorman (Dr.)
VOLUNTARY HEALTH INSURANCE BOARD
Ireland
EU contribution
€ 374 518,80
Address
Lower Abbey Street 20 Vhi House
1 Dublin
Activity type
Other
Administrative Contact
Bernadette Carr (Dr.)
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
Spain
EU contribution
€ 1 003 638,48
Address
Carrer Baldiri Reixac 10-12 Parc Scientific De Barcelona
08028 Barcelona
Activity type
Research Organisations
Administrative Contact
Adriana Grosu (Ms.)
FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE
Spain
EU contribution
€ 560 800
Address
Avenida Gran Via Hospitalet 199-203
08908 L'hospitalet De Llobregat
Activity type
Research Organisations
Administrative Contact
Laia Lagunas (Ms.)
TEKNOLOGIAN TUTKIMUSKESKUS VTT

Participation ended

Finland
EU contribution
€ 431 364,67
Address
Tekniikantie 4 A
02044 VTT Espoo
Activity type
Research Organisations
Administrative Contact
Jing Tang (Dr.)
ITA-SUOMEN YLIOPISTO
Finland
EU contribution
€ 232 480
Address
Yliopistonranta 1 E
70211 Kuopio
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Tiina Reinikainen (Ms.)
METABOLON INC CORPORATION
United States
EU contribution
€ 554 395,88
Address
Research Triangle Park
27709 Durham Nc
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Walter Gall (Dr.)
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
EU contribution
€ 282 770
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Amanda Gregory (Dr.)
PINTAIL LTD
Ireland
EU contribution
€ 198 724
Address
Springhill Avenue 77
A94 K542 Blackrock
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Ciaran Clissmann (Mr.)