Objective Healthy brain ageing is a major determinant of quality life-long health, allowing integration into society at all ages. Human epidemiological and animal studies indicate that in addition to life style and genetic factors, environmental influences in prenatal life have a major impact on brain ageing and age-associated brain disorders. We hypothesize that: (1) prenatal stress programs early brain ageing; (2) this predisposes to age-associated brain diseases including cognitive decline and stroke; (3) epigenetic changes affecting glucocorticoid receptor (GR) sensitivity, altered autonomic nervous system (ANS) reactivity and cerebrovascular tone are important mediators of these processes, (4) these changes represent targets for diagnosis and therapeutic interventions.Our consortium has unique access to well-defined human and non-human primate cohorts (age range 25-115 y equivalents) that have been exposed to different types of prenatal stress. For experimental analysis of mechanisms of prenatal programming, we apply innovative techniques to characterize brain ageing, namely MRI based volumetry, non-linear analysis of EEG and ANS, advanced molecular techniques including epigenetics and metabolomics and neuropsychological and behavioral tests.Human subjects, non-human primates and rodents (including transgenic models) exposed to maternal stress, glucocorticoids or undernutrition are examined in order to: (1) determine structural (MRI based volumetry) and functional (metabolomics, brain function, cerebrovascular tone) indicators of brain age, (2) relate them to susceptibility to stroke and cognitive decline, (3) determine to what extent GR resistance, stress sensitivity, and cerebrovascular contractility mediate premature brain ageing and disease susceptibility; and, (4) dissect mechanisms and pharmacological interventions relevant for aged subjects. Data from the study allow to identify subjects at risk for premature brain ageing and to initiate interventional therapy. Fields of science natural sciencesbiological scienceszoologymammalogyprimatologynatural sciencesbiological sciencesneurobiologymedical and health sciencesbasic medicineneurologystrokenatural sciencesbiological sciencesgeneticsepigenetics Programme(s) FP7-HEALTH - Specific Programme "Cooperation": Health Topic(s) HEALTH.2011.2.2.2-2 - Linking human development and ageing Call for proposal FP7-HEALTH-2011-two-stage See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITATSKLINIKUM JENA Address Kastanienstr.1 07747 Jena Germany See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Administrative Contact Matthias Schwab (Prof.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all LEIBNIZ-INSTITUT FUR ALTERNSFORSCHUNG - FRITZ-LIPMANN-INSTITUT EV (FLI) LEIBNIZ INSTITUTE ON AGING - FRITZ LIPMANN INSTITUTE EV (FLI) Germany EU contribution € 269 544,00 Address Beutenbergstrasse 11 07745 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Babette Scherneck (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data KATHOLIEKE UNIVERSITEIT LEUVEN Belgium EU contribution € 71 428,80 Address Oude markt 13 3000 Leuven See on map Region Vlaams Gewest Prov. Vlaams-Brabant Arr. Leuven Activity type Higher or Secondary Education Establishments Administrative Contact Elke Lammertyn (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE UNIVERSITY OF TEXAS SYSTEM Participation ended United States EU contribution € 271 766,25 Address Colorado street 601 78701 2982 Austin See on map Activity type Higher or Secondary Education Establishments Administrative Contact Chris Green (Mr.) Links Contact the organisation Opens in new window Other funding No data BIOCRATES LIFE SCIENCES AG Austria EU contribution € 303 585,60 Address Eduard bodem gasse 8 1 stock 6020 Innsbruck See on map Region Westösterreich Tirol Innsbruck Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Denise Sonntag (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM Netherlands EU contribution € 355 542,40 Address Meibergdreef 15 1105AZ Amsterdam See on map Region West-Nederland Noord-Holland Groot-Amsterdam Activity type Higher or Secondary Education Establishments Administrative Contact Salena Voorneman Links Contact the organisation Opens in new window Website Opens in new window Other funding No data LIFE LENGTH SL Spain EU contribution € 115 800,00 Address Calle miguel angel 11 2 planta 28010 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Stephen Matlin (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data TILBURG UNIVERSITY- UNIVERSITEIT VAN TILBURG Netherlands EU contribution € 217 279,20 Address Warandelaan 2 5037 AB Tilburg See on map Region Zuid-Nederland Noord-Brabant Midden-Noord-Brabant Activity type Higher or Secondary Education Establishments Administrative Contact Jane Pinas (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAET ULM Germany EU contribution € 216 144,00 Address Helmholtzstrasse 16 89081 Ulm See on map Region Baden-Württemberg Tübingen Ulm, Stadtkreis Activity type Higher or Secondary Education Establishments Administrative Contact Jerg Reiner (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF WYOMING United States EU contribution € 101 034,15 Address 1000 e. university avenue, department 3355 82071 Laramie, wy See on map Activity type Higher or Secondary Education Establishments Administrative Contact Linda Gay Osterman Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
