Objective The goal of the AnastomoSEAL project is to develop a biomaterial for tissue engineering for the age-related colorectal cancer (CRC), aiming at increasing the quality of life of patients as well as decreasing the costs of health and long term care. CRC is the second commonest form of cancer in Europe, with an aged-standardized incidence rate of 48 cases per 100’000 in 2008 (data from European Cancer Observatory), mostly affecting elderly people. The most frequent post-operative complication of any bowel resection is the “Anastomotic Leakage” (AL) which occurs up to 21% of cases, after suturing the resected bowel extremities. The project aims to satisfy the widespread clinical need of preventing AL after CRC resection. The objective of the project is the development of a degradable biomaterial, specifically capable of promoting a safe anastomosis during the critical period of tissue healing. We propose to design an innovative biomaterial in form of patch inserted by the surgeon after the anastomotic procedure which wraps around the sutured tissue to reinforce and seal the external part of the intestine, preventing AL and inducing tissue regeneration. The biomaterial will be based on natural polysaccharides alginate and hyaluronic acid (and its butyrate ester), and it will be designed to adhere to the intestinal tissue and to remain in situ for the required time. The goal of the project is to produce a resorbable reinforcing medical device specifically designed to aid rapid sealing and healing of colon-rectal anastomoses. At present, no such specific material for clinical use is available on the market. This device has the potential to become the material of choice for a non-invasive technique and represents an opportunity for the European companies involved in the project to pursue innovation in the biomaterial market. The AnastomoSEAL Consortium involves 2 academic and 4 industrial partners, integrating the RTD chain from material design to pre-clinical testing. Fields of science medical and health sciencesmedical biotechnologytissue engineeringmedical and health sciencesclinical medicineoncologycolorectal cancernatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesengineering and technologyindustrial biotechnologybiomaterials Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2011.2.2-2 - Biomaterials for tissue engineering for age-related cancer and sensory organ diseases Call for proposal FP7-NMP-2011-SMALL-5 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator UNIVERSITA DEGLI STUDI DI TRIESTE Address Piazzale europa 1 34127 Trieste Italy See on map Region Nord-Est Friuli-Venezia Giulia Trieste Activity type Higher or Secondary Education Establishments Administrative Contact Paolo Balsini (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (5) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITEIT MAASTRICHT Netherlands EU contribution € 465 731,00 Address Minderbroedersberg 4 6200 MD Maastricht See on map Region Zuid-Nederland Limburg (NL) Zuid-Limburg Activity type Higher or Secondary Education Establishments Administrative Contact Joseph Ih Janssen (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data SIGEA SRL Italy EU contribution € 402 482,00 Address Localita padriciano 99 34012 Trieste See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Felice Scoccimarro (Dr.) Links Contact the organisation Opens in new window Other funding No data RESCOLL France EU contribution € 445 620,00 Address Allee geoffroy saint hilaire 8 cs 30021 33600 Pessac See on map Region Nouvelle-Aquitaine Aquitaine Gironde Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Konstantin Sipos (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FMC BIOPOLYMER AS Norway EU contribution € 393 125,00 Address Industriveien 33 1337 Sandvika See on map Region Norge Oslo og Viken Viken Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Kristen Jester (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data FEDIUK WLADYSLAW Poland EU contribution € 222 400,00 Address See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Wladyslaw Fediuk (Mr.) Links Contact the organisation Opens in new window Other funding No data
