Objective Despite the increasing number of macromolecules with potential impact in the treatment of devastating systemic diseases, these therapies have failed to deliver on their expectations because they cannot be administered in the fashion which is most cost efficient and has the highest patient compliance: the oral route. The availability of an oral form of administration could lead to a great improvement of classical therapies and it would also make a high number of new therapies feasible. To make this happen, the final objective of Trans-INT is to design nanocarriers specifically adapted to deal with the gastrointestinal ecosystem and use them for the development of new oral nanomedicines for diseases with high socioeconomic impact (i.e. metabolic diseases, pain medication).The concept behind TRANS-INT is the rational design of oral nanomedicines based on safety, mechanistic, bioengineering (multifunctional nanocarriers: high payload, drug protection, efficient drug transport, controlled release) and pharmaceutical technology criteria (scalable technology and stability). The project will start with nanocarrier platforms on which the partners have IPR and freedom to operate: nanocapsules, nanoparticles, micelles made of combinations of lipids, polypeptides and polysaccharides, continue with the optimization and redefinition of selected nanocarriers. It is expected to end with (i) at least one oral nanocarrier prototype with a comprehensive GLP-tox package, which could be applied for the delivery of a high number of peptide molecules, (ii) at least one nanomedicine fulfilling target product profile criteria, with a comprehensive preclinical evaluation package, (iii) substantial integrative knowledge on the feasibility and potential of oral nanocarriers and nanopharmaceuticals. TRANS-INT is expected to have a great impact no only from the new therapies/patients perspective but also from the innovation and EU industrial development perspective. Fields of science medical and health sciencesbasic medicinepharmacology and pharmacypharmaceutical drugsnatural sciencesbiological sciencesbiochemistrybiomoleculeslipidsmedical and health sciencesmedical biotechnologynanomedicinenatural sciencesbiological sciencesbiochemistrybiomoleculescarbohydratesengineering and technologynanotechnologynano-materials Programme(s) FP7-NMP - Specific Programme "Cooperation": Nanosciences, Nanotechnologies, Materials and new Production Technologies Topic(s) NMP.2011.1.2-2 - New targeted therapy using nanotechnology for transport of macro-molecules across biological barriers Call for proposal FP7-NMP-2011-LARGE-5 See other projects for this call Funding Scheme CP-IP - Large-scale integrating project Coordinator UNIVERSIDAD DE SANTIAGO DE COMPOSTELA EU contribution € 1 665 013,76 Address COLEXIO DE SAN XEROME PRAZA DO OBRADOIRO S/N 15782 Santiago De Compostela Spain See on map Region Noroeste Galicia A Coruña Activity type Higher or Secondary Education Establishments Administrative Contact Martin Cacheiro Martinez (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data Participants (17) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN Ireland EU contribution € 654 159,40 Address BELFIELD 4 Dublin See on map Region Ireland Eastern and Midland Dublin Activity type Higher or Secondary Education Establishments Administrative Contact Donal Doolan (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE CATHOLIQUE DE LOUVAIN Belgium EU contribution € 506 920,00 Address PLACE DE L UNIVERSITE 1 1348 Louvain La Neuve See on map Region Région wallonne Prov. Brabant Wallon Arr. Nivelles Activity type Higher or Secondary Education Establishments Administrative Contact Véronique Préat (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES France EU contribution € 355 755,23 Address RUE LEBLANC 25 75015 PARIS 15 See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Administrative Contact Aloïse Mabondzo (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE LONDON EU contribution € 699 576,00 Address GOWER STREET WC1E 6BT LONDON See on map Activity type Higher or Secondary Education Establishments Administrative Contact Greta Borg-Carbott (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ADVANCELL ADVANCED IN VITRO CELL TECHNOLOGIES S.A Participation ended Spain EU contribution No data Address CALLE BALDARI I REIXACH 10 08028 Barcelona See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Vila Pena Ana Isabel (Dr.) Links Contact the organisation Opens in new window Total cost No data VENETO NANOTECH SOCIETA CONSORTILEPER AZIONI Participation ended Italy EU contribution € 117 477,29 Address PIAZZA SALVEMINI 13 35131 Padova See on map Region Nord-Est Veneto Padova Activity type Research Organisations Administrative Contact Roberta Mitidieri (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SUBLIMITY THERAPEUTICS LIMITED Ireland EU contribution € 390 900,00 Address INVENT CENTRE DUBLIN CITY UNIVERSITY 9 DUBLIN See on map Region Ireland Eastern and Midland Dublin Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Ivan S Coulter (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITE D'ANGERS France EU contribution € 558 305,22 Address RUE DE RENNES 40 49035 Angers Cedex 01 See on map Region Pays de la Loire Pays de la Loire Maine-et-Loire Activity type Higher or Secondary Education Establishments Administrative Contact Jean-Pierre Benoit (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data MEDIZINISCHE HOCHSCHULE HANNOVER Germany EU contribution € 434 880,00 Address Carl-Neuberg-Strasse 1 30625 Hannover See on map Region Niedersachsen Hannover Region Hannover Activity type Higher or Secondary Education Establishments Administrative Contact Frank Dittrich (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA) Spain EU contribution € 302 040,00 Address CARRER BALDIRI REIXAC 10-12 PARC SCIENTIFIC DE BARCELONA 08028 Barcelona See on map Region Este Cataluña Barcelona Activity type Research Organisations Administrative Contact Alexandre Puerto Valdivieso (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UPPSALA UNIVERSITET Sweden EU contribution € 449 436,40 Address VON KRAEMERS ALLE 4 751 05 Uppsala See on map Region Östra Sverige Östra Mellansverige Uppsala län Activity type Higher or Secondary Education Establishments Administrative Contact Eva Nises Ahlgren (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ISTITUTO ONCOLOGICO VENETO Italy EU contribution € 301 400,00 Address VIA GATTAMELATA 64 35128 Padova See on map Region Nord-Est Veneto Padova Activity type Research Organisations Administrative Contact Manuela Mtanis (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SEROSCIENCE KUTATO FEJLESZTO ES KERESKEDELMI KORLATOLT FELELOSSEGU TARSASAG Hungary EU contribution € 346 320,00 Address LORANT UTCA 10 B EP FSZT 2 1125 Budapest See on map Region Közép-Magyarország Budapest Budapest Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Janos Csukás (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data SANOFI-AVENTIS RECHERCHE & DEVELOPPEMENT France EU contribution € 616 154,00 Address 82 AVENUE RASPAIL 94250 GENTILLY See on map Region Ile-de-France Ile-de-France Val-de-Marne Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Denis Croisat (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data F. HOFFMANN-LA ROCHE AG Participation ended Switzerland EU contribution No data Address GRENZACHERSTRASSE 124 4070 Basel See on map Region Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Barbara Lueckel (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK Ireland EU contribution € 459 100,00 Address WESTERN ROAD T12 YN60 Cork See on map Region Ireland Southern South-East Activity type Higher or Secondary Education Establishments Administrative Contact David O'connell (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data ECAMRICERT SRL Italy EU contribution € 142 562,70 Address VIALE DEL LAVORO 6 36030 Monte Di Malo See on map Region Nord-Est Veneto Vicenza Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Nicola Dalle Molle (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
