Objective
Alcoholism, a major health issue worldwide, is characterized by high rates of relapse. Stress/anxiety probably contribute to relapse vulnerability and are the topic of this proposal.
To determine the role in addiction of novel genes such as PKCe, which is regulated by alcohol, behavioural analysis of knockout mice is required. During her PhD project, H.
Lesscher studied cocaine reinforcement in µ-opioid receptor mutant mice. With this, she was the first in the Rudolf Magnus Institute of Neuroscience to set up addiction-related research in mice. However, she and the laboratory would benefit from refinement of the behavioural paradigms, which is the rationale behind this application.
The host institute, Dr. Messing's laboratory at the Ernest Gallo Clinic and Research Centre, is well experienced with mouse behaviour, particularly anxiety and alcoholism.
This proposal will investigate amygdala CRF regulation in the context of alcohol withdrawal-induced anxiety and alcohol consumption in PKCe null mice. Recent studies in Dr. Messing's laboratory have shown that PKCe null mice are less anxious, consume less alcohol and display a reduced 'alcohol deprivation effect' as compared to wild-type mice.
Further, amygdala CRF, GABAA activity and plasma corticosterone deviate from wild-type. This proposal will therefore investigate, in PKCe null mice, the relation between alcohol withdrawal-induced anxiety and alcohol consumption and the underlying mechanisms.
Upon returning to the Netherlands, H. Lesscher will implement t he skills and experience gained to investigate opioid gene x environment interactions in drug reinforcement, thereby improving the competitiveness of European addiction researchers.
This international training at the Gallo Centre will further increase the probability of H. Lesscher receiving extramural funding to pursue her scientific career with an excellent research background applied to a field with high clinical relevance.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences microbiology virology
- natural sciences chemical sciences organic chemistry alcohols
- natural sciences biological sciences genetics RNA
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
UTRECHT
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.