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POLARITY AND SUBCELLULAR DYNAMICS IN PLANTS

Objective

Plant life strategy is marked by acquisition of highly flexible development that adapts plants’ phenotype to the environment. Various environmental signals are integrated into the endogenous signalling networks involving the versatile phytohormone auxin. The intercellular auxin transport mediates a large variety of adaptive plant growth responses. Subcellular polar distribution of PIN auxin transporters determines directionality of auxin flow and thus have potential to integrate internal and external signals via the redirection of auxin fluxes and translate them into modulation of development. Auxin transport thus represents a unique model for studying the functional link between basic cellular processes, such as vesicle trafficking and cell polarity, and their developmental outcome at the level of the multicellular organism.
We will employ approaches of cell biology, molecular genetics and chemical genomics in Arabidopsis thaliana to identify the cellular and molecular mechanisms regulating the directional throughput of auxin flow a integration of environmental signals into subcellular dynamics of PIN auxin transporters as well as endogenous feed-back regulations of this mechanism.
In our proposal, we will focus on four main research directions.

1. Novel regulators of cell polarity identified by chemical genomics
2. Cellular mechanisms of cell polarity maintenance
3. Integration of signals into subcellular dynamics of auxin transport
4. Mathematical modelling of regulatory circuits for adaptive development

The results will demonstrate the viability of genetics approaches for addressing cell biological questions in plants, open new horizons in plant cell biology and plant hormone fields and inspire researchers also in non-plant fields. The expected output has clear application potential for targeted modulation of plant development. The project will further strengthen our position of world-leading laboratory in plant hormone and plant cell biology fields.

Field of science

  • /social sciences/social and economic geography/transport
  • /natural sciences/biological sciences/genetics and heredity
  • /natural sciences/biological sciences/molecular biology/molecular genetics
  • /natural sciences/biological sciences/cell biology/cell polarity

Call for proposal

ERC-2011-StG_20101109
See other projects for this call

Funding Scheme

ERC-SG - ERC Starting Grant

Host institution

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Address
Am Campus 1
3400 Klosterneuburg
Austria
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 268 855,32
Principal investigator
Jiří Friml (Prof.)
Administrative Contact
Carla Mazuheli-Chibidziura (Ms.)

Beneficiaries (2)

INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA
Austria
EU contribution
€ 1 268 855,32
Address
Am Campus 1
3400 Klosterneuburg
Activity type
Higher or Secondary Education Establishments
Principal investigator
Jiří Friml (Prof.)
Administrative Contact
Carla Mazuheli-Chibidziura (Ms.)
VIB VZW

Participation ended

Belgium
EU contribution
€ 231 144,68
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Administrative Contact
Rik Audenaert (Mr.)