ICT-enabled, cellular artificial liver system incorporating personalized patient management and support

Informations projet

d-LIVER

N° de convention de subvention: 287596

Projet clôturé

Date de début 1 Octobre 2011

Date de fin 30 Septembre 2015

Financé au titre de

• Specific Programme "Cooperation": Information and communication technologies

Coût total € 14 309 163,00

Contribution de l’UE € 10 959 000,00

Coordonné par

UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom

Description du projet

Personal Health Systems (PHS)

d-LIVER applies scenario-driven development methodologies to address an unmet need for bio-artificial liver support via continuous detoxification as remote transient therapy at the Point-of-Need. The liver is a complex organ with various vital functions in synthesis, detoxification and regulation; its failure is life-threatening and the only curative treatment is transplantation. Whilst awaiting transplantation, or after liver resection, patients need to be supported with detoxification systems which, currently mainly based on filtration, do not support metabolic liver function. This can only be provided by living cells. Thus, development of ICT-enabled bio-artificial liver support systems with associated remote monitoring to assist in the treatment and management of liver patients in care settings extending from the hospital to the home is essential.d-LIVER targets sensor-based monitoring of patient health status at home, concentrating on continuous monitoring of physiological parameters and discrete measurement of a defined set of biochemical species. d-LIVER also targets remote monitoring and control of the bio-artificial liver and communication with patient sensor networks and hospital information systems. Systems will be capable of remote, secure communication of the status of both the patient and the bio-artificial liver to central clinical services such that they can schedule swift and beneficial treatment and remedial actions. In this way d-LIVER will provide fundamental advances in liver support by reducing hospitalisation costs while enhancing quality of care and, at the same time, reinforcing European leadership in Personal Health systems.In a parallel, high-risk, activity the production of human hepatocytes from pancreatic progenitor cells will be investigated. These would be ideal for use in d-LIVER systems since they may provide an unlimited supply of hepatocytes, which would overcome drawbacks associated with both primary hepatocytes and stem cells.

Champ scientifique

• engineering and technology › electrical engineering, electronic engineering, information engineering › electronic engineering › sensors › smart sensors
• medical and health sciences › medical biotechnology › cells technologies › stem cells
• medical and health sciences › clinical medicine › transplantation
• medical and health sciences › medical biotechnology › tissue engineering › bioartificial liver

Programme(s)

• FP7-ICT - Specific Programme "Cooperation": Information and communication technologies

Thème(s)

• ICT-2011.5.1 - Personal Health Systems (PHS)

Appel à propositions

FP7-ICT-2011-7
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Régime de financement

CP - Collaborative project (generic)

Coordinateur

UNIVERSITY OF NEWCASTLE UPON TYNE

• Contribution de l’UE: € 1 537 149,00
• Adresse: KINGS GATE ; NE1 7RU Newcastle Upon Tyne ; Royaume-Uni
• Région: North East (England) › Northumberland and Tyne and Wear › Tyneside
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Helen Gallon (Ms.)
• Coût total: Aucune donnée

Participants (14)

CSEM CENTRE SUISSE D'ELECTRONIQUE ET DE MICROTECHNIQUE SA - RECHERCHE ET DEVELOPPEMENT

Suisse

• Contribution de l’UE: € 998 209,00
• Adresse: RUE JAQUET DROZ 1 ; 2000 Neuchatel
• Région: Schweiz/Suisse/Svizzera › Espace Mittelland › Neuchâtel
• Type d’activité: Research Organisations
• Contact administratif: Christiane Duerig (Ms.)
• Coût total: Aucune donnée

INSTITUT FUER MIKROTECHNIK MAINZ GMBH

Participation terminée

Allemagne

• Contribution de l’UE: € 449 413,00
• Adresse: Carl-Zeiss-Str. 18-20 ; 55129 Mainz
• Type d’activité: Research Organisations
• Contact administratif: Frank Hainel (Dr.)
• Coût total: Aucune donnée

STEM CELL SYSTEMS GMBH

Allemagne

• Contribution de l’UE: € 201 900,00
• Adresse: FLUGHAFEN TEMPELHOF, HANGAR VI ; 12101 BERLIN
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Thomas BOLD (Mr.)
• Coût total: Aucune donnée

enablingMNT GMBH

Allemagne

• Contribution de l’UE: € 234 300,00
• Adresse: HOLSTEINISCHE STR 23 ; 12161 BERLIN
• Région: Berlin › Berlin › Berlin
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Patric SALOMON (Mr.)
• Coût total: Aucune donnée

STAR HEALTHCARE MANAGEMENT GMBH

Allemagne

• Contribution de l’UE: € 299 700,00
• Adresse: PIERSTR 8 ; 50997 KOELN
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Simone ROEBBECKE (Ms.)
• Coût total: Aucune donnée

FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV

Allemagne

• Contribution de l’UE: € 1 934 086,00
• Adresse: HANSASTRASSE 27C ; 80686 Munchen
• Région: Bayern › Oberbayern › München, Kreisfreie Stadt
• Type d’activité: Research Organisations
• Contact administratif: Andrea Zeumann (Ms.)
• Coût total: Aucune donnée

CHARITE - UNIVERSITAETSMEDIZIN BERLIN

Allemagne

• Contribution de l’UE: € 1 100 996,00
• Adresse: Chariteplatz 1 ; 10117 Berlin
• Région: Berlin › Berlin › Berlin
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Eveline Fräßdorf
• Coût total: Aucune donnée

DEKRA TESTING AND CERTIFICATION SAU

Espagne

• Contribution de l’UE: € 282 350,00
• Adresse: CALLE SEVERO OCHOA 2 PARQUE TECNOLOGICO CAMPANILLAS ; 29590 Malaga
• Région: Sur › Andalucía › Málaga
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Janie Banos (Ms.)
• Coût total: Aucune donnée

UNIVERSITAT ROVIRA I VIRGILI

Espagne

• Contribution de l’UE: € 836 266,00
• Adresse: CARRER DE ESCORXADOR ; 43003 Tarragona
• Région: Este › Cataluña › Tarragona
• Type d’activité: Higher or Secondary Education Establishments
• Contact administratif: Rosa Solà i Alberich (Prof.)
• Coût total: Aucune donnée

COMMISSARIAT A L ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES

France

• Contribution de l’UE: € 1 166 597,00
• Adresse: RUE LEBLANC 25 ; 75015 PARIS 15
• Région: Ile-de-France › Ile-de-France › Paris
• Type d’activité: Research Organisations
• Contact administratif: Olivier HATEM (Mr.)
• Coût total: Aucune donnée

HUMANITAS MIRASOLE SPA

Italie

• Contribution de l’UE: € 36 000,00
• Adresse: VIA MANZONI 56 ; 20100 Rozzano (Mi)
• Région: Nord-Ovest › Lombardia › Milano
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: DANILO PETRONI (Mr.)
• Coût total: Aucune donnée

Olivetti I-Jet

Participation terminée

Italie

• Contribution de l’UE: € 27 800,00
• Adresse: LOCALITA LE VIEUX ; 11020 ARNAD
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: Alessandro BELLONE (Dr.)
• Coût total: Aucune donnée

STIFTELSEN SINTEF

Norvège

• Contribution de l’UE: € 1 434 274,00
• Adresse: STRINDVEIEN 4 ; 7034 Trondheim
• Région: Norge › Trøndelag › Trøndelag
• Type d’activité: Research Organisations
• Contact administratif: Dag AUSEN (Mr.)
• Coût total: Aucune donnée

IXSCIENT LIMITED

Royaume-Uni

• Contribution de l’UE: € 419 960,00
• Adresse: POPES GROVE 76 ; TW1 4JX Twickenham Middlesex
• Région: London › Outer London — West and North West › Hounslow and Richmond upon Thames
• Type d’activité: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Contact administratif: David WENN (Mr.)
• Coût total: Aucune donnée