Objective There is a need for greater understanding of integrated cellular physiology to exploit cells and to tailor their activities to optimise microbial productivity in synthetic circuits and to limit microbial activity in food and pharmaceutical products. Understanding the integration of the cellular metabolic processes is fundamental to developing and exploiting cells. We have assembled a team of internationally renowned academic and industrial partners to form a training network comprising experimentalists and modellers. The partners will work synergistically to generate a cohort of well-trained young scientists with multidisciplinary skills to drive this research field forward and provide novel tools for academic and industrial research.Our focus in this training programme is a thorough understanding of cytoplasmic homeostasis, because this is integral to the functioning of individual components and whole pathways. Cytoplasmic homeostasis is amenable to both experimentation and modelling and has profound implications for the core processes of life and productivity.The research objectives are:• To advance our understanding of the homeostatic mechanisms of bacteria via predictive modelling and state-of-the-art experimental approaches.• To generate deep insights into effects of perturbation of homeostasis on the core properties of the cell: transcription, translation, metabolism and control over protein activity.• To develop novel approaches to gauge the properties of individual cells and to model the behaviour of single cells, cell collectives in biofilms and multicellular structures.• To develop new chemical and biophysical tools for the analysis of cells and protein complexes in order to understand cellular sub-structure assembly.• To map the location and dynamics of supramolecular assemblies in the cytoplasm and cell membranes.• To manipulate the productivity of the cell and engineer new, tailored activities in the cell for industrial needs. Fields of science natural sciencesbiological sciencesmicrobiologybacteriologynatural sciencesbiological sciencesbiochemistrybiomoleculesproteinsnatural sciencesbiological sciencescell biologysocial scienceseconomics and businesseconomicsproduction economicsproductivitymedical and health sciencesbasic medicinephysiologyhomeostasis Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-ITN - Marie-Curie Action: "Initial Training Networks" Call for proposal FP7-PEOPLE-2011-ITN See other projects for this call Funding Scheme MC-ITN - Networks for Initial Training (ITN) Coordinator RIJKSUNIVERSITEIT GRONINGEN Address Broerstraat 5 9712CP Groningen Netherlands See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Administrative Contact Jan Poutsma (Dr.) Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (7) Sort alphabetically Sort by EU Contribution Expand all Collapse all UNIVERSITAET POTSDAM Germany EU contribution € 523 652,79 Address Am neuen palais 10 14469 Potsdam See on map Region Brandenburg Brandenburg Potsdam Activity type Higher or Secondary Education Establishments Administrative Contact Regina Gerber (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITY OF ABERDEEN United Kingdom EU contribution € 854 001,50 Address King's college regent walk AB24 3FX Aberdeen See on map Region Scotland North Eastern Scotland Aberdeen City and Aberdeenshire Activity type Higher or Secondary Education Establishments Administrative Contact Kerry Kidd (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Germany EU contribution € 226 626,40 Address Hofgartenstrasse 8 80539 Munchen See on map Region Bayern Oberbayern München, Kreisfreie Stadt Activity type Research Organisations Administrative Contact Reinhard Lipowsky (Prof.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS Spain EU contribution € 456 409,80 Address Calle serrano 117 28006 Madrid See on map Region Comunidad de Madrid Comunidad de Madrid Madrid Activity type Research Organisations Administrative Contact Eusebio Jimenez Arroyo (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD United Kingdom EU contribution € 228 388,60 Address Wellington square university offices OX1 2JD Oxford See on map Region South East (England) Berkshire, Buckinghamshire and Oxfordshire Oxfordshire Activity type Higher or Secondary Education Establishments Administrative Contact Stephen Conway (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DSM FOOD SPECIALTIES BV Netherlands EU contribution € 211 850,10 Address Alexander fleminglaan 1 2613 AX Delft See on map Region West-Nederland Zuid-Holland Delft en Westland Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact Roel Bovenberg (Mr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data ASTRAZENECA UK LIMITED United Kingdom EU contribution € 261 200,51 Address 1 francis crick avenue cambridge biomedical campus CB2 0AA Cambridge See on map Region East of England East Anglia Cambridgeshire CC Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Administrative Contact James Yates (Dr.) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
