Skip to main content

Network for Integrated Cellular Homeostasis

Objective

There is a need for greater understanding of integrated cellular physiology to exploit cells and to tailor their activities to optimise microbial productivity in synthetic circuits and to limit microbial activity in food and pharmaceutical products. Understanding the integration of the cellular metabolic processes is fundamental to developing and exploiting cells. We have assembled a team of internationally renowned academic and industrial partners to form a training network comprising experimentalists and modellers. The partners will work synergistically to generate a cohort of well-trained young scientists with multidisciplinary skills to drive this research field forward and provide novel tools for academic and industrial research.

Our focus in this training programme is a thorough understanding of cytoplasmic homeostasis, because this is integral to the functioning of individual components and whole pathways. Cytoplasmic homeostasis is amenable to both experimentation and modelling and has profound implications for the core processes of life and productivity.

The research objectives are:
• To advance our understanding of the homeostatic mechanisms of bacteria via predictive modelling and state-of-the-art experimental approaches.
• To generate deep insights into effects of perturbation of homeostasis on the core properties of the cell: transcription, translation, metabolism and control over protein activity.
• To develop novel approaches to gauge the properties of individual cells and to model the behaviour of single cells, cell collectives in biofilms and multicellular structures.
• To develop new chemical and biophysical tools for the analysis of cells and protein complexes in order to understand cellular sub-structure assembly.
• To map the location and dynamics of supramolecular assemblies in the cytoplasm and cell membranes.
• To manipulate the productivity of the cell and engineer new, tailored activities in the cell for industrial needs.

Field of science

  • /social sciences/economics and business/economics/production economics/productivity
  • /medical and health sciences/basic medicine/physiology/homeostasis
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/pharmaceutical drug

Call for proposal

FP7-PEOPLE-2011-ITN
See other projects for this call

Funding Scheme

MC-ITN - Networks for Initial Training (ITN)
Leaflet | Map data © OpenStreetMap contributors, Credit: EC-GISCO, © EuroGeographics for the administrative boundaries

Coordinator

RIJKSUNIVERSITEIT GRONINGEN
Address
Broerstraat 5
9712CP Groningen
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 731 125,46
Administrative Contact
Jan Poutsma (Dr.)

Participants (7)

UNIVERSITAET POTSDAM
Germany
EU contribution
€ 523 652,79
Address
Am Neuen Palais 10
14469 Potsdam
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Regina Gerber (Dr.)
THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
United Kingdom
EU contribution
€ 854 001,50
Address
King's College Regent Walk
AB24 3FX Aberdeen
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Kerry Kidd (Ms.)
Klinik Max Planck Institut für Psychiatrie
Germany
EU contribution
€ 226 626,40
Address
Hofgartenstrasse 8
80539 Muenchen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Reinhard Lipowsky (Prof.)
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS
Spain
EU contribution
€ 456 409,80
Address
Calle Serrano 117
28006 Madrid
Activity type
Research Organisations
Administrative Contact
Eusebio Jimenez Arroyo (Mr.)
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 228 388,60
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
DSM FOOD SPECIALTIES BV
Netherlands
EU contribution
€ 211 850,10
Address
Alexander Fleminglaan 1
2613 AX Delft
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Roel Bovenberg (Mr.)
ASTRAZENECA UK LIMITED
United Kingdom
EU contribution
€ 261 200,51
Address
1 Francis Crick Avenue Cambridge Biomedical Campus
CB2 0AA Cambridge
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
James Yates (Dr.)