Objective There is a high societal need for a sustainable production of key chemistry, food and health care compounds. Microbial cell factories are logical production systems, but up to now they use sugars and other food derived raw materials as substrates. Sugars originating from plants demand cultivable land which is more and more needed for human nutrition. Methanol - with a worldwide production capacity of more than 46 million tons per year - is regarded as an alternative highly attractive raw material in microbial fermentation for the manufacturing of special, fine, bulk, and fuel chemicals. This is especially true for the EU market, where industrial biotechnology still is hampered by strict use and price regulations as well as import limitations for agricultural commodities, such as corn or sugar. The supply of methanol can base upon both fossil and renewable resources, rendering it a highly flexible and sustainable raw material. Our vision is a viable methanol-based European bio-economy, which we will promote by for the first time applying synthetic biology principles for cell factory development in order to harness methanol as a general feedstock for the manufacturing of special and fine chemicals. In nature, methylotrophic microorganisms can utilize methanol as their sole source of carbon and energy. The project PROMYSE will deliver an alternative route to sought-after chemicals, with a major focus on terpenoids. PROMYSE combines two frontline research topics: orthogonal modularization of methylotrophy within a Synthetic Biology concept and employing methanol as a feedstock for biotechnological production. Through the transfer of methylotrophy modules, Synthetic Biology will pave the way to capitalize on the metabolic versatility and engineered production pathways of genetically well tractable microorganisms, such as E. coli, B. subtilis and C. glutamicum for biotransformation from methanol. Fields of science natural sciencesbiological sciencessynthetic biologynatural scienceschemical sciencesorganic chemistryalcoholsengineering and technologyenvironmental engineeringenergy and fuelsnatural sciencesbiological sciencesmicrobiologyengineering and technologyindustrial biotechnologybioprocessing technologiesfermentation Programme(s) FP7-KBBE - Specific Programme "Cooperation": Food, Agriculture and Biotechnology Topic(s) KBBE.2011.3.6-04 - Applying Synthetic Biology principles towards the cell factory notion in biotechnology Call for proposal FP7-KBBE-2011-5 See other projects for this call Funding Scheme CP-FP - Small or medium-scale focused research project Coordinator STIFTELSEN SINTEF Address Strindveien 4 7034 Trondheim Norway See on map Region Norge Trøndelag Trøndelag Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window EU contribution No data Participants (9) Sort alphabetically Sort by EU Contribution Expand all Collapse all EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Switzerland EU contribution € 399 423,00 Address Raemistrasse 101 8092 Zuerich See on map Region Schweiz/Suisse/Svizzera Zürich Zürich Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data UNIVERSITAET BIELEFELD Germany EU contribution € 388 500,00 Address Universitaetsstrasse 25 33615 Bielefeld See on map Region Nordrhein-Westfalen Detmold Bielefeld, Kreisfreie Stadt Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data RIJKSUNIVERSITEIT GRONINGEN Netherlands EU contribution € 390 349,00 Address Broerstraat 5 9712CP Groningen See on map Region Noord-Nederland Groningen Overig Groningen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE TOULOUSE France EU contribution € 390 521,00 Address Avenue de rangueil 135 31077 Toulouse cedex 4 See on map Region Occitanie Midi-Pyrénées Haute-Garonne Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DECHEMA-FORSCHUNGSINSTITUT STIFTUNG Germany EU contribution € 390 060,00 Address Theodor heuss allee 25 60486 Frankfurt See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Other funding No data INSILICO BIOTECHNOLOGY AG Germany EU contribution € 275 700,00 Address Meitnerstrasse 9 70563 Stuttgart See on map Region Baden-Württemberg Stuttgart Stuttgart, Stadtkreis Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data PROMAR AS Norway EU contribution € 112 908,00 Address Rolfsbuktveien 17 1364 Fornebu See on map Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data BASF SE Germany EU contribution € 55 985,00 Address Carl bosch strasse 38 67063 Ludwigshafen am rhein See on map Region Rheinland-Pfalz Rheinhessen-Pfalz Ludwigshafen am Rhein, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Other funding No data DECHEMA GESELLSCHAFT FUR CHEMISCHETECHNIK UND BIOTECHNOLOGIE Germany EU contribution € 0,00 Address Theodor heuss allee 25 60486 Frankfurt See on map Region Hessen Darmstadt Frankfurt am Main, Kreisfreie Stadt Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Other funding No data
