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Nanocapsules for targeted delivery of radioactivity

Objective

The consortium RADDEL (RADioactivity DELivery) has a research-based approach for the training of the new generation of scientists in the development of novel functional nanomaterials . A well structured training program will be provided with a balanced combination of local and network-wide training through secondments, joint network meetings, workshops, schools, industrial training and the final network conference. The research program focuses on the design, synthesis, characterisation, pharmacological studies and dosimetry calculations of nanocapsules that seal in their interior radioactive materials for biomedical applications in the areas of cancer diagnosis and therapy. After sealing the chosen radionuclides, the external walls of the nanocapsules will be decorated with biomolecules to render them biocompatible and for targeting purposes. In a recent study we have recently observed that these nanocapsules allow the delivery of unprecedented radiodosage and remain stable for extended periods thus guaranteeing essentially zero leakage of the radionuclides. Surface functionalisation of these nanocapsules offers versatility towards modulation of tissue biodistribution of the radioemitting crystals in a manner determined by the nanocapsule that delivers them. The delivery of radioactivity takes place through the walls of nanocapsules (carbon) and release of the encapsulated radionuclides is therefore not needed and certainly not desired. The present research objectives go beyond the-state-of-the art in the field and innovative products and solutions are expected.

Call for proposal

FP7-PEOPLE-2011-ITN
See other projects for this call

Coordinator

AGENCIA ESTATAL CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS
Address
Calle Serrano 117
28006 Madrid
Spain
Activity type
Research Organisations
EU contribution
€ 894 821,40
Administrative Contact
Alberto Sereno Alvarez (Mr.)

Participants (9)

THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
United Kingdom
EU contribution
€ 650 511,40
Address
Wellington Square University Offices
OX1 2JD Oxford
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Stephen Conway (Dr.)
KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 535 610,39
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Paul Labbett (Mr.)
UNIVERSITA DEGLI STUDI DI TRIESTE
Italy
EU contribution
€ 363 183,70
Address
Piazzale Europa 1
34127 Trieste
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Edda Bartole (Ms.)
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
France
EU contribution
€ 375 302,40
Address
Rue Michel Ange 3
75794 Paris
Activity type
Other
Administrative Contact
Christine Brunel (Ms.)
FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA
Spain
EU contribution
€ 236 069,90
Address
Campus De La Uab Edifici Q Icn2
08193 Bellaterra (Barcelona)
Activity type
Research Organisations
Administrative Contact
Marta Balza (Ms.)
PANEPISTIMIO IOANNINON
Greece
EU contribution
€ 227 860,60
Address
Panepistemioypole Panepistemio Ioanninon
45110 Ioannina
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Georgios Detsikas (Mr.)
USTAV FYZIKALNI CHEMIE J. HEYROVSKEHO AV CR, v. v. i.
Czechia
EU contribution
€ 218 545,80
Address
Dolejskova 2155/3
182 23 Praha
Activity type
Other
Administrative Contact
Martin Kalbac (Dr.)
CIS BIO INTERNATIONAL SAS
France
EU contribution
€ 229 488,51
Address
Rn Saclay 306
91192 Gif Sur Yvette Cedex
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Administrative Contact
Jean-Claude Saccavini (Dr.)
THE UNIVERSITY OF MANCHESTER
United Kingdom
EU contribution
€ 118 366
Address
Oxford Road
M13 9PL Manchester
Activity type
Higher or Secondary Education Establishments
Administrative Contact
Claire Faichnie (Ms.)