Objective
The recent approaches to Alzheimer’s and Parkinson’s diseases reflect the current concepts of copper(II) and iron(III) involvement in the ethiology of these disorders. Therefore, the development of imaging tools capable of sensing the distribution of these two deleterious metals as well as the design of novel treatment strategies are currently at the focus of attention. In my return project to the Faculty of Chemistry, University of Wroclaw, Poland, and in the framework of internationa l scientific collaborations, I would like to study new chelators designed to selectively bind copper(II) and iron(III) cations and to pass the blood-brain-barrier. A series of ligands possessing two or three bidentate groups based on oxygen and nitrogen do nor sets will be examined. The attachement of the fluorescent probes to these compounds or the presence of fluorescent binding sites will lead to a quenching process induced by the coordination of copper(II) and iron(III) and provide very sensitive analyti cal tool for the determination of traces of these cations. This phenomenon could also be used to image and localise accumulations of these metals in physiological tissues. A powerful combination of potentiometry, absorption and emission spectrophotometry a nd electrospray mass spectrometry will be used to determine the stoichiometry of the cupric and ferric complexes and the corresponding stability constants. Zn(II) and Ga(III) will be chosen as probes of Cu(II) and Fe(III) respectively for NMR measurements. Cyclic voltammetry will be used to determine the electrochemical properties of the metal complexes as well as the electron transfer mechanisms. The coordination processes of Cu(II) and Fe(III) with the newly synthesised ligands will be also determined by kinetic measurements in the milliseconds range. The predictive information given by the key steps will guide the strategy of synthesis of new ferric and cupric ligands and probes.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors
- medical and health sciences basic medicine neurology parkinson
- natural sciences chemical sciences analytical chemistry mass spectrometry
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Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
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Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
WROCLAW
Poland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.