Objective
MAPK pathways transmit signals from the environment to the cellular machinery, eliciting responses that are specific for each stimulus. These pathways are essential for the survival of unicellular or complex eukaryotes. In higher eukaryotes, the improper regulation of MAPK pathways is at the core of some illnesses like inflammatory diseases or cancer.
MAPK pathways have been the subject of intense study for the last 15 years. The basic components of many of these pathways have been described and analysed in a large number of eukaryotes. However, little is known about how the MAPKKs are down regulated and the effects of this inactivation in the cell physiology. We will study the regulation of one of the key components of a MAPK pathway in the yeast Schizosacchar omyces pombe, the MAPKK Wis1. The MAPKK Wis1 is a key component of the Spc1 MAPK pathway in fission yeast.
The Spc1 pathway responds to high osmolarity, oxidative stress, heat shock, etc. In response to stress, Wis1 is activated by phosphorylation mediated by the MAPKKKs, Wis4 and Win1, and in turn, phosphorylates and activates the MAPK Spc1. We will try to understand how Wis1 is inactivated and how this inactivation is achieved, through the study of novel components of this pathway. The information obtained will be useful for the understanding of MAPK pathways in other eukaryotes and the development of specific drugs that target these pathways.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences clinical medicine oncology
- medical and health sciences basic medicine physiology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.