Objective
With natural product-derived (or inspired) molecules used as drugs in almost all branches of medicine, natural products play a key role in our pharmacopoeia. Among natural product producers, Streptomyces are remarkable for their ability to produce an unriv alled range of chemically diverse secondary metabolites, displaying a wide range of biological activities such as antibiotic, immunosuppressant or antitumor activities. Pyrrole amides constitute a family of natural products produced by Streptomyces and rel ated actinobacteria. Their ability to bind DNA in the minor groove confer them a variety of biological activities. Moreover, two of the best known members of the family, congocidine and distamycin, have attracted considerable attention as they have been sh own to bind DNA in a sequence-specific manner. The aim of this project is to elucidate the biosynthetic pathways of two related pyrrole amides, congocidine and distamycin, and to use the knowledge gained from these studies to engineer analogues of these mo lecules and generate new biologically active molecules. The congocidine biosynthetic gene cluster, which has already been identified in the host institution, represents the first known pyrrole amide biosynthetic gene cluster and shows promising novel featu res for combinatorial biosynthesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences health sciences infectious diseases RNA viruses HIV
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs antibiotics
- medical and health sciences basic medicine neurology stroke
- medical and health sciences basic medicine pharmacology and pharmacy drug resistance antibiotic resistance
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-11
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
ORSAY
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.