Objective
Adult mesenchymal stem cells (MSCs) contribute to maintenance of connective tissues and regeneration of tissues damaged in disease. MSCs are depleted and functionally altered in osteoarthritis. However, the contribution of this stem cell deficit on the etiology of osteoarthritis is unknown.
The purpose of this research is to examine the role that MSCs play in the development of degenerative joint disease and the underlying mechanism of altered MSC differentiation in OA will be a central focus of the proposal. This proposal will elucidate mechanisms of stem cell differentiation both in vivo and in vitro and will have a significant impact in defining the role of stem cells in osteoarthritis and in particular on the contribution of a stem cell deficit function to disease progression.
In addition this research will contribute significantly to elucidation of the mechanisms the therapeutic efficacy of stem cells in osteoarthritis. This research will break new ground in osteoarthritis and stem cell research and may ultimately lead to the design and development of novel therapies for not only this disease but also allow the development of therapies for other diseases.
The funds requested in this proposal will be used to facilitate re-integration of an EU citizen who has trained and worked in the US for over 14 years and has recently moved to take up a position in the newly established Regenerative Medicine Institute (REMEDI) at NUI Galway in Ireland.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- natural sciences biological sciences genetics DNA
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences genetics epigenetics
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
GALWAY
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.