Objective
Although associations between psychosocial stress and health outcomes have now been carefully documented for several diseases, the mechanisms by which stress specifically influence disease susceptibility, activity and outcome are poorly understood. This proposal focus on the role of stress hormones in the regulation of pro-inflammatory and anti-inflammatory cytokine production for 2 major reasons: (1) the balance of pro-inflammatory/ T helper (Th)1 versus anti-inflammatory/Th2 cytokine production is critically skewed, one way or the other, in several common human diseases such as infections, allergy, autoimmunity and atherosclerosis; (2) hyperactivity or hypoactivity of the stress system influence the onset and/or the course of the above-mentioned diseases. Thus, better understanding of the stress system regulation of Th1, Th2 and pro-/anti-inflammatory cytokine responses may provide critical insights into mechanisms underlying a variety of common human immune-related diseases.
Over the past decade others and we have shown that stress hormones inhibit the production of Th1 cytokines but stimulate the production of Th2 cytokines. Taking into consideration the above-mentioned important clinical implications, further studies in this direction are warranted.
The major objectives of this grant application are:
(1) further extend the work of the applicant in this field;
(2) support the reintegration of the applicant and transfer of knowledge acquired in the USA;
(3) complement a Marie Curie Chair proposal of the applicant;
(4) support the continued development of an existing multidisciplinary organizational structure.
The research project will focus on:
(1) effect of stress hormones on the production of newly described Th1 and Th2 cytokines;
(2) neural-immune interact ions at the vascular wall and
(3) interactions between stress system activity and cytokine profiles in inbred strains of rats, with implications for allergy, autoimmunity and atherosclerosis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences basic medicine immunology autoimmune diseases
- medical and health sciences clinical medicine allergology
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-12
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
IRG - Marie Curie actions-International re-integration grants
Coordinator
ROME
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.