Objective
Morphogenesis refers to the set of complex movements and deformations that tissues experience during development to give rise to the three dimensional form of organs and organisms. From a biomechanical perspective tissues represent a unique class of materials, which exhibit dynamic mechanical properties that evolve over time. Little is known about how these macroscopic properties arise from the interplay and integration of molecular, cellular and tissue events. In this project, I propose to use the process of Dorsal Closure of the Drosophila embryo to undertake a dynamic study of morphogenesis spanning the molecular, cellular and tissue levels, to obtain insights into how tissue properties emerge from the coordinated activity of its constituent cells. These studies will focus on the amnioserosa, one of the main force-generating tissues during DC that has proved to be a powerful system to study the emergence of morphogenetic forces. The focus of this project is to understand the molecular mechanisms underlying actomyosin activity, how they translate into effective cell shape changes and how this activity is coordinated across the whole tissue to give rise to the contractile activity of the tissue. For this, I will use a combination of classical genetics and state of the art microscope techniques to obtain quantitative information on the dynamic behaviour of molecules, sub-cellular modules and cells. I will investigate how molecular and cellular events impinge on the mechanical properties of the tissue, which will be probed by laser ablation experiments in wild type and in embryos with perturbed actomyosin dynamics. The multi-disciplinary research outlined in this project has the potential to make significant contributions to the young field of cell-developmental biology and the physical and engineering sciences.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics
- natural sciences physical sciences optics microscopy
- medical and health sciences clinical medicine embryology
- natural sciences physical sciences optics laser physics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
28006 MADRID
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.