Objective
Cellix Ltd., a spin-out instrumentation company from Trinity College Dublin, are experts in the area of nanotechnology and microfluidics having developed new and exciting microfluidic based technologies providing cell based assay solutions to advance basic science, medicine and drug discovery. The Academic partner is the Allergic and Asthmatic Inflammation group, School of Medicine, University of Aberdeen (UNIABDN) whose work focuses on the cells and mediators responsible for the initiation and resolution of inflammation in asthmatic and allergic disease.
Asthma is now the most common chronic disease in westernised countries. It is a complex syndrome characterised by a variable degree of airway obstruction in which the fundamental abnormality is airway inflammation. One key area of ongoing work is furthering understanding of how an important pro-inflammatory effector cell in asthma, the eosinophil, selectively accumulates in the asthmatic lung. Central to this is an understanding of how eosinophils transmigrate from the blood vessels of the lung into the surrounding tissues where they exert their pro-inflammatory effects. This proposal combines proven expertise in leukocyte adhesion and transmigration (UA) with expertise in microflow adhesion of high throughput assays (Cellix).
The development of the resulting platform technology will be used to identify therapeutic targets for asthma and to apply these novel technologies to other human diseases with a significant inflammatory component. By identifying those immunomodulators that facilitate/block adhesion and transmigration processes in an in vitro setting, prior to using an animal model, pharmaceutical companies would be able to remove/include such compounds from down-stream processing, thereby eliminating false leads earlier reducing the drug development cycle and cost. The new area of competence to be developed will require a multi-disciplinary effort and this is one of the key benefits of the ToK approach.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine pharmacology and pharmacy drug discovery
- natural sciences physical sciences classical mechanics fluid mechanics microfluidics
- medical and health sciences clinical medicine pneumology asthma
- engineering and technology nanotechnology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2004-MOBILITY-3
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
DUBLIN
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.