Cardiovascular Risk from Exposure to Low-dose and Low-dose-rate Ionizing Radiation

Project Information

PROCARDIO

Grant agreement ID: 295823

Project closed

Start date 1 October 2011

End date 31 March 2015

Funded under

• EURATOM: Nuclear fission and radiation protection

Total cost € 5 489 075,40

EU contribution € 2 998 386,60

Coordinated by

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH
Germany

Objective

Epidemiological evidence has established a link between cardiovascular disease and exposure of the heart and major vessels to doses above 500mGy. At lower doses the evidence for a detrimental effect is inconclusive. In part, this is due to the lack of appropriate epidemiological studies, coupled with lack of knowledge of the processes involved that is needed for construction of mathematical models. The ProCardio consortium will study cardiovascular outcomes in childhood cancer survivors where the radiation doses given to the heart are available. These data will be interrogated using new mathematical models developed from the data from our molecular and biological studies. These will use state-of-the-art technologies to map cardiovascular changes after photon irradiation at both low doses and low dose rates. This will be complemented by comparative studies using high LET irradiation. We will apply an integrative approach to combine transcriptional (mRNA and miRNA) and translational (proteomics) studies to understand the disease processes. High throughput proteomics (ICPL, SILAC and label-free analysis) will be used to identify new biomarkers of radiation-induced cardiovascular disease for future molecular epidemiological studies. These will be validated using the archives of cardiovascular tissue samples from the Mayak facility.

Fields of science

• natural sciences › biological sciences › biochemistry › biomolecules › proteins › proteomics
• natural sciences › physical sciences › nuclear physics
• medical and health sciences › clinical medicine › cardiology › cardiovascular diseases
• medical and health sciences › clinical medicine › oncology
• natural sciences › mathematics › applied mathematics › mathematical model

Programme(s)

• FP7-EURATOM-FISSION - EURATOM: Nuclear fission and radiation protection

Topic(s)

• Fission-2011-3.1.1 - Contribution to low-dose risk research in Europe

Call for proposal

FP7-Fission-2011
See other projects for this call

Funding Scheme

CP-FP - Small or medium-scale focused research project

Coordinator

HELMHOLTZ ZENTRUM MUENCHEN DEUTSCHES FORSCHUNGSZENTRUM FUER GESUNDHEIT UND UMWELT GMBH

• EU contribution: € 679 796,00
• Address: INGOLSTADTER LANDSTRASSE 1 ; 85764 Neuherberg ; Germany
• Region: Bayern › Oberbayern › München, Landkreis
• Activity type: Research Organisations
• Administrative Contact: Jürgen Ertel (Dr.)
• Total cost: No data

Participants (12)

FUNDACIO CENTRE DE RECERCA EN EPIDEMIOLOGIA AMBIENTAL - CREAL

Spain

• EU contribution: € 218 800,00
• Address: Calle Doctor Aiguader 88 ; 08003 BARCELONA
• Activity type: Research Organisations
• Administrative Contact: Joana Porcel (Ms.)
• Total cost: No data

INSTITUT GUSTAVE ROUSSY

France

• EU contribution: € 269 560,00
• Address: Rue Camille Desmoulins 39 ; 94805 Villejuif
• Region: Ile-de-France › Ile-de-France › Val-de-Marne
• Activity type: Research Organisations
• Administrative Contact: Arnauld Forest (Mr.)
• Total cost: No data

GSI HELMHOLTZZENTRUM FUR SCHWERIONENFORSCHUNG GMBH

Germany

• EU contribution: € 240 000,00
• Address: PLANCKSTRASSE 1 ; 64291 Darmstadt
• Region: Hessen › Darmstadt › Darmstadt, Kreisfreie Stadt
• Activity type: Other
• Administrative Contact: Doris Scholz (Ms.)
• Total cost: No data

HEALTH PROTECTION AGENCY HPA

Participation ended

United Kingdom

• EU contribution: € 76 338,04
• Address: BUCKINGHAM PALACE ROAD 151 ; SW1W 9SZ London
• Activity type: Research Organisations
• Administrative Contact: Anne Dempsey (Ms.)
• Total cost: No data

AGENZIA NAZIONALE PER LE NUOVE TECNOLOGIE, L'ENERGIA E LO SVILUPPO ECONOMICO SOSTENIBILE

Italy

• EU contribution: € 184 995,00
• Address: LUNGOTEVERE GRANDE AMMIRAGLIO THAON DI REVEL 76 ; 00196 Roma
• Region: Centro (IT) › Lazio › Roma
• Activity type: Research Organisations
• Administrative Contact: Anna Saran (Dr.)
• Total cost: No data

STUDIECENTRUM VOOR KERNENERGIE / CENTRE D'ETUDE DE L'ENERGIE NUCLEAIRE

Belgium

• EU contribution: € 231 200,00
• Address: AVENUE HERRMANN DEBROUX 40 ; 1160 Bruxelles / Brussel
• Region: Région de Bruxelles-Capitale/Brussels Hoofdstedelijk Gewest › Région de Bruxelles-Capitale/ Brussels Hoofdstedelijk Gewest › Arr. de Bruxelles-Capitale/Arr. Brussel-Hoofdstad
• Activity type: Research Organisations
• Administrative Contact: Nathalie Impens (Dr.)
• Total cost: No data

GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG

Germany

• EU contribution: € 229 999,60
• Address: OSKAR VON MILLER RING 29 ; 80333 Muenchen
• Region: Bayern › Oberbayern › München, Kreisfreie Stadt
• Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
• Administrative Contact: Birgit Fuchs (Ms.)
• Total cost: No data

THE UNIVERSITY OF BIRMINGHAM

United Kingdom

• EU contribution: € 330 000,00
• Address: Edgbaston ; B15 2TT Birmingham
• Region: West Midlands (England) › West Midlands › Birmingham
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: May Chung (Ms.)
• Total cost: No data

RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU

Netherlands

• EU contribution: € 154 998,00
• Address: Antonie Van Leeuwenhoeklaan 9 ; 3721 MA Bilthoven
• Region: West-Nederland › Utrecht › Utrecht
• Activity type: Research Organisations
• Administrative Contact: Thedo Blijdenstein (Dr.)
• Total cost: No data

FEDERAL STATE UNITARY ENTERPRISE SOUTHERN URALS BIOPHYSICS INSTITUTE OF FEDERAL MEDICOBIOLOGICAL AGENCY

Russia

• EU contribution: € 200 000,00
• Address: OZYORSKOE SHOSSE 19 ; 456780 OZYORSK
• Activity type: Research Organisations
• Administrative Contact: Tamara Azizova (Dr.)
• Total cost: No data

ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM

Netherlands

• EU contribution: € 80 000,00
• Address: MEIBERGDREEF 15 ; 1105AZ Amsterdam
• Region: West-Nederland › Noord-Holland › Groot-Amsterdam
• Activity type: Higher or Secondary Education Establishments
• Administrative Contact: Leontien Kremer (Dr.)
• Total cost: No data

Department of Health

United Kingdom

• EU contribution: € 102 699,96
• Address: Quarry House, Quarry Hill ; LS2 7UE Leeds
• Region: Yorkshire and the Humber › West Yorkshire › Leeds
• Activity type: Research Organisations
• Administrative Contact: Anne Dempsey (Mrs.)
• Total cost: No data