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Directed evolution of class B G-protein coupled receptors


A generic selection system for improved expression and thermostability of G protein-coupled receptors by directed evolution.

Author(s): Christoph Klenk,Andreas Plückthun,Marco Schütz,Janosch Ehrenmann
Published in: Springer Science and Business Media LLC 2016
Permanent ID: Digital Object Identifier:10.1038/srep21294,PubMed Central ID:PMC4758055,PubMed ID:26887595,Digital Object Identifier:10.5167/uzh-125014

Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists

Author(s): Jendrik Schöppe,Janosch Ehrenmann,Christoph Klenk,Prakash Rucktooa,Marco Schütz,Andrew S. Doré,Andreas Plückthun
Published in: Nature Publishing Group Schöppe, Jendrik; Ehrenmann, Janosch; Klenk, Christoph; Rucktooa, Prakash; Schütz, Marco; Doré, Andrew S; Plückthun, Andreas (2019). Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nature Communications, 10(1):17. 2019
Permanent ID: Digital Object Identifier:10.1038/s41467-018-07939-8,Digital Object Identifier:10.5167/uzh-174004,PubMed ID:30604743,PubMed Central ID:PMC6318301

Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools

Author(s): Yufan Wu,Lutz Kummer,Erik Sedlák,Seymour de Picciotto,Andreas Plückthun,Renato Zenobi,Christoph Klenk,Alexander Batyuk,Basri Gulbakan,Marco Schütz,Peer R. E. Mittl,K. Dane Wittrup,Jendrik Schöppe,Gregory A. Newby,Franziska Zosel
Permanent ID: Digital Object Identifier:10.1016/j.jmb.2016.01.017,PubMed ID:26812208,Digital Object Identifier:10.5167/uzh-124939