Objective "The goal of this proposal is to develop efficient strategies for the nuclear magnetic resonance (NMR) crystallography of organic molecular solids, focussing on nucleic acids and their derivatives. These systems are natural targets for the developing field of crystallography via NMR since H-bonding and tautomerism are central to their biological activity. The structure and function of RNA and DNA depends strongly on associated metal ions and with water molecules, but the non-covalent and dynamic nature of these interactions creates severe problems for their characterisation in the solution state, while characterising the role of water and hydrogen bonding in the solid state via X-ray diffraction techniques is also difficult. As well as providing a variety of challenges for NMR, such as paramagnetic metal ions, these studies will provide direct information on local structure and dynamics in these key biological materials that is inaccessible to conventional crystallography." Fields of science natural sciencesbiological sciencesbiochemistrybiomoleculesnucleic acidsnatural sciencesbiological sciencesgeneticsDNAnatural sciencesearth and related environmental sciencesgeologymineralogycrystallographynatural sciencesbiological sciencesgeneticsRNA Programme(s) FP7-PEOPLE - Specific programme "People" implementing the Seventh Framework Programme of the European Community for research, technological development and demonstration activities (2007 to 2013) Topic(s) FP7-PEOPLE-2011-IEF - Marie-Curie Action: "Intra-European fellowships for career development" Call for proposal FP7-PEOPLE-2011-IEF See other projects for this call Funding Scheme MC-IEF - Intra-European Fellowships (IEF) Coordinator UNIVERSITY OF DURHAM EU contribution € 156 775,05 Address STOCKTON ROAD THE PALATINE CENTRE DH1 3LE Durham United Kingdom See on map Region North East (England) Tees Valley and Durham Durham CC Activity type Higher or Secondary Education Establishments Administrative Contact Wendy Harle (Ms.) Links Contact the organisation Opens in new window Website Opens in new window Total cost No data
