Objective
Graphs are used in modern neuroscience to represent structural and functional connectivity of the brain acquired using magnetic resonance imaging. A number of pathologies affect these networks: their study holds vast promise for understanding and diagnosing brain diseases. But brain connectivity data is not trivial to process, and the predominant graph-theoretical analysis approach is used mostly at the group level. This project aims at developing imaging markers of neurodegenerative diseases based on recognition of functional and structural connectivity patterns of the brain at rest, for use predictively at the single patient level. The methods will be complementary to existing imaging modalities and clinical practice. The project will address two important tied questions: 1) How can we extract connectivity graphs from neuroimaging data, and perform inference on such graphs? 2) What are the confounds in the subjects or data processing that may impede clinical application of the methods?
These questions will be addressed by new theoretical work and experiments with data from early multiple sclerosis and Alzheimer's disease patients. Data preprocessing and estimation of functional connectivity will be evaluated and improved, new algorithms to compare functional and structural connectivity graphs will be developed, and novel multimodal machine learning techniques will be developed to leverage the structural/functional connectivity interaction. Differences in connectivity due to physiological noise, pathological changes, and scanning site will be modelled in depth, and methods for compensating for such confounding factors will be evaluated.
The project will advance novel imaging markers with high clinical relevance for two very prevalent neurological diseases in the EU. The project's dissemination stance will foster EU excellence in the emerging science of connectomics, and the fellowship will equip the researcher with skills vastly improving his scientific standing.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology dementia alzheimer
- medical and health sciences basic medicine neurology multiple sclerosis
- medical and health sciences basic medicine pathology
- engineering and technology medical engineering diagnostic imaging magnetic resonance imaging
- natural sciences computer and information sciences data science data processing
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IOF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1211 Geneve
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.