Objective
As well as controlling patterning, morphogens such as the Drosophila BMP homolog Decapentaplegic (Dpp) also regulate growth during development, but how they do so remains largely unclear. One privileged hypothesis, called the steepness hypothesis, suggests that cells in a tissue read spatial differences in the morphogen gradient and divide accordingly. However, the host lab recently discovered a novel mechanism by which the Dpp gradient controls growth: in the Drosophila wing disc, cells are able to read temporal differences in the Dpp gradient and regulate their cell cycle accordingly. More precisely, cells divide when their Dpp signalling level has increased by a constant percentage alpha since the start of their current cell cycle.
Using biophysical methods, I will expand this work and study the molecular mechanisms coupling proliferation control with temporal changes in the Dpp gradient. I will generate cell cycle biosensors in order to monitor cell cycle parameters and their evolution throughout wing development, using fixed samples but also thanks to live imaging. I will also analyse the cell cycle and Dpp gradient characteristics in different tumourigenic conditions, in the hope to uncover general principles governing tumour formation. Finally, as several interactions have been uncovered between Dpp signalling and the tumour suppressor Hippo pathway, I will assess thanks to cell culture as well as in vivo assays whether the Hippo pathway could mediate the continued sensitivity of cells to the temporal Dpp signalling increase throughout development.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology electrical engineering, electronic engineering, information engineering electronic engineering sensors biosensors
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
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Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
1211 Geneve
Switzerland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.