Objective
"The expression of CD20 is generally assumed to be restricted to lymphocytes of the B-cell lineage. However, there is accumulating evidence that a small subpopulation of T-cells also express CD20. These CD20+ T-cells, which might be described as “insane in their membrane”, were first reported in 1993. The role of these cells in the immune system, however, has never been addressed. The preliminary data presented in the current proposal indicates that the vast majority of these CD20+ T-cells are in fact effector memory T-cells (TEM). Moreover, preliminary data implicate these CD20+ TEM cells in the pathogenesis of Rheumatoid Arthritis (RA) and Ovarian Cancer (OC). In RA patients, these CD20+ TEM cells secrete large amounts of the pro-inflammatory cytokine IL-17. In OC patients, CD20+ TEM cells account for a striking 20% of all resident T-cells in the peritoneal fluid of patients. Taken together, these findings suggest that CD20+ TEM cells may represent a thus far neglected, but important, immune cell population involved in the pathogenesis of major human diseases like auto-immunity and cancer.
The aim of the current proposal is to determine the origin and function of CD20+ TEM cells in healthy individuals, and determine their involvement in auto-immune and cancer progression.
To this end, we will determine the precise phenotype of CD20+ TEM cells, their broad antigen-specificity, and changes that occur within this population during RA/OC progression. In addition, we will determine if CD20+ T-cells can be induced from naive T-cells. Finally, we will perform preliminary experiments to determine whether CD20+ T-cells might be used for cancer immunotherapy, or selectively eliminated for treatment of auto-immune disease."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-IEF
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Coordinator
EX4 4QJ Exeter
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.