Objective
Recently, within the borders of a Marie Curie IEF project, we have established zebrafish as a novel exercise model and demonstrated the stimulation of growth by exercise in adult zebrafish (Palstra et al., PLoS ONE, 2010). Exercise may also induce hypertrophy and cardiomyocyte proliferation in zebrafish making it an important model to study vertebrate heart regeneration and improved robustness of fish in aquaculture. Moreover, zebrafish has been recently recognized as a valuable model for immunological studies since they possess an adaptive and innate immune system similar to mammals. Given the beneficial effects of exercise on mammalian immune function, zebrafish can be used to investigate exercise-induced stimulation of immune function.
In this project we propose to use this novel exercise model for human and fish and, by applying state-of-the-art techniques, to demonstrate the mechanisms behind the beneficial exercise effects of enhanced skeletal and cardiac muscle growth and immune functioning, and to exercise glucocorticoid knock out and transgenic zebrafish to assess the role of the cortisol stress response at the base of these beneficial exercise effects.
SWIMFIT will enable the development of a novel research line on exercise integrating the applicant’s existing expertise on exercise physiology with applying high throughput genomic, transcriptomic and proteomic methodology thereby creating a new scientific niche.
At the Institute for Marine Resources and Ecosystem Studies (IMARES) of the Wageningen University, the applicant has postulated a position as researcher aquaculture and is investigating the opportunities for implementation of exercise in aquaculture. Besides these applied studies, this Marie Curie reintegration grant would offer the opportunity to deepen the initiated fundamental studies on zebrafish to demonstrate the functional mechanisms behind the beneficial effects of swimming using all the advantages that zebrafish offers as a model fish.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- medical and health sciences basic medicine immunology
- medical and health sciences basic medicine physiology
- natural sciences biological sciences zoology mammalogy
- medical and health sciences health sciences sport and fitness sciences
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP7-PEOPLE-2011-CIG
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MC-CIG - Support for training and career development of researcher (CIG)
Coordinator
6708 PB Wageningen
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.